Nelson Daniel A, Nirmaier Jamie L, Singh Sam J, Tolbert Melanie D, Bost Kenneth L
Department of Biology, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC 28223, USA.
Brain Behav Immun. 2008 Aug;22(6):912-22. doi: 10.1016/j.bbi.2008.01.002. Epub 2008 Feb 15.
While Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) has been shown to modulate immune responses, no studies have addressed drug-induced alterations to viral infection. In this study, bone marrow-derived macrophages were exposed to MDMA, then infected with murine gammaherpesvirus-68, and the expression of monokines assessed. MDMA-induced reductions in virus-stimulated monokine mRNA expression were observed in a dose-dependent manner. In particular, IL-6 mRNA expression and secretion was significantly decreased in gammaherpesvirus-infected macrophages exposed to MDMA. Concentrations of MDMA capable of reducing monokine production did not induce significant cell death and allowed normal viral gene expression. These studies represent the first to demonstrate the ability of this drug of abuse to alter a viral-induced macrophage response.
虽然摇头丸（3,4-亚甲基二氧甲基苯丙胺，MDMA）已被证明可调节免疫反应，但尚无研究探讨药物诱导的病毒感染变化。在本研究中，将骨髓来源的巨噬细胞暴露于MDMA，然后用鼠γ-疱疹病毒-68感染，并评估单核因子的表达。观察到MDMA以剂量依赖性方式降低病毒刺激的单核因子mRNA表达。特别是，暴露于MDMA的γ-疱疹病毒感染的巨噬细胞中IL-6 mRNA表达和分泌显著降低。能够减少单核因子产生的MDMA浓度不会诱导明显的细胞死亡，并允许正常的病毒基因表达。这些研究首次证明了这种滥用药物改变病毒诱导的巨噬细胞反应的能力。
