Higashi K, Jin Y, Johansson M, Heim S, Mandahl N, Biörklund A, Wennerberg J, Hambraeus G, Johansson L, Mitelman F
Department of Clinical Genetics, Lund University Hospital, Sweden.
Genes Chromosomes Cancer. 1991 Jan;3(1):21-3. doi: 10.1002/gcc.2870030105.
Two adenoid cystic carcinomas, one of the nasal cavity, the other a bronchial tumor, were cytogenetically analyzed. The former had a t(6;9)(q21-22;p 13-21) as the sole karyotypic abnormality. The latter had two related abnormal clones, resulting in the mosaic karyotype 46,XY,t(9;17)(p13;p13)/46,Y,t(X;6)(p22;q23),t(9;17)(p13;p13). The karyotypic profiles of the two cases, the only respiratory tract adenoid cystic carcinomas that have been cytogenetically characterized, differ little from those of previously reported adenoid cystic carcinomas of the major salivary glands, underscoring the fundamental biologic similarity among these tumors even when they develop from different structures and in different anatomical sites and organs. Because in the second case the t(9;17) obviously must have preceded the t(X;6), we conclude that both tumors had rearrangement of 9p13 as the primary cytogenetic change. The data thus add to the evidence that 6q changes are frequent, albeit at least sometimes secondary, aberrations in malignant salivary gland tumors. A subset of adenoid cystic carcinomas instead have rearrangement of 9p as the primary, and presumably pathogenetically essential, abnormality.
对两例腺样囊性癌进行了细胞遗传学分析，其中一例为鼻腔腺样囊性癌，另一例为支气管肿瘤。前者唯一的核型异常为t(6;9)(q21 - 22;p13 - 21)。后者有两个相关的异常克隆，形成嵌合核型46,XY,t(9;17)(p13;p13)/46,Y,t(X;6)(p22;q23),t(9;17)(p13;p13)。这两例是仅有的经细胞遗传学特征分析的呼吸道腺样囊性癌，其核型图谱与先前报道的主要涎腺腺样囊性癌的核型图谱差异不大，这突出了这些肿瘤之间基本的生物学相似性，即使它们起源于不同的结构以及不同的解剖部位和器官。由于在第二例中t(9;17)显然必定先于t(X;6)出现，我们得出结论，这两种肿瘤都以9p13重排作为主要的细胞遗传学改变。这些数据因此进一步证明，6q改变在恶性涎腺肿瘤中很常见，尽管至少有时是继发性畸变。相反，一部分腺样囊性癌以9p重排作为主要的、推测在发病机制上至关重要的异常。
