el-Naggar A K, Lovell M, Callender D L, Killary A M
Department of Pathology, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
Cancer Genet Cytogenet. 1999 Feb;109(1):66-9. doi: 10.1016/s0165-4608(98)00188-5.
We present the cytogenetic, interphase fluorescence in-situ hybridization (FISH) and DNA content findings in a clinically aggressive adenoid cystic carcinoma (ADCC) of the parotid gland. The tumor manifested diploid chromosomal and DNA content by cytogenetic, interphase FISH and flow cytometry. G-banding analysis revealed inv(5)(p15.2q33) and t(6;15)(q25;q15) as the only structural alterations in all 30 metaphases examined. The limited structural abnormalities found in this recurrent lesion suggest that they may constitute a primary or early event in the development of this tumor. The involvement of 6q region in our tumor and in some of the previously reported ADCC supports the association between this region and the evolution of at least a subset of these tumors.
我们展示了腮腺临床侵袭性腺样囊性癌（ADCC）的细胞遗传学、间期荧光原位杂交（FISH）和DNA含量研究结果。通过细胞遗传学、间期FISH和流式细胞术分析，该肿瘤表现为二倍体染色体和DNA含量。G显带分析显示，在所检查的全部30个中期相中，inv(5)(p15.2q33)和t(6;15)(q25;q15)是仅有的结构改变。在这个复发性病变中发现的有限结构异常表明，它们可能是该肿瘤发生过程中的原发性或早期事件。我们的肿瘤以及之前报道的部分ADCC中6q区域受累，支持了该区域与这些肿瘤至少一部分亚群的进展之间存在关联。
