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本文引用的文献

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Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains.人类4Ig-B7-H3的分子特征，B7家族中具有四个免疫球蛋白样结构域的成员。
J Immunol. 2004 Feb 15;172(4):2352-9. doi: 10.4049/jimmunol.172.4.2352.
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Mouse B7-H3 induces antitumor immunity.小鼠B7-H3可诱导抗肿瘤免疫。
Gene Ther. 2003 Sep;10(20):1728-34. doi: 10.1038/sj.gt.3302070.
3
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses.B7家族成员B7-H3优先下调1型辅助性T细胞介导的免疫反应。
Nat Immunol. 2003 Sep;4(9):899-906. doi: 10.1038/ni967. Epub 2003 Aug 17.
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Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss.灵长类和啮齿动物B7-H3免疫球蛋白V样和C样结构域的复制：功能冗余和外显子丢失的不同历史
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Expression, purification, and biochemical characterization of Chk, a soluble protein tyrosine kinase.可溶性蛋白酪氨酸激酶Chk的表达、纯化及生化特性分析
Protein Expr Purif. 2003 Jun;29(2):148-55. doi: 10.1016/s1046-5928(02)00698-8.
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Spinning molecular immunology into successful immunotherapy.将旋转分子免疫学转化为成功的免疫疗法。
Nat Rev Immunol. 2002 Apr;2(4):227-38. doi: 10.1038/nri774.
7
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.B7-DC，一种对T细胞具有强大共刺激特性的新型树突状细胞分子。
J Exp Med. 2001 Apr 2;193(7):839-46. doi: 10.1084/jem.193.7.839.
8
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.B7-H1是B7家族的第三个成员，它共刺激T细胞增殖和白细胞介素-10的分泌。
Nat Med. 1999 Dec;5(12):1365-9. doi: 10.1038/70932.

共刺激分子B7-H3表达与胃癌组织学及预后的关系。

Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis.

作者信息

Wu Chang-Ping, Jiang Jing-Ting, Tan Min, Zhu Yi-Bei, Ji Mei, Xu Kuan-Feng, Zhao Jie-Min, Zhang Guang-Bo, Zhang Xue-Guang

机构信息

The Third Affiliated Hospital of Suzhou University, Changzhou 213003, Jiangsu Province, China.

出版信息

World J Gastroenterol. 2006 Jan 21;12(3):457-9. doi: 10.3748/wjg.v12.i3.457.

DOI:10.3748/wjg.v12.i3.457
PMID:16489649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4066068/
Abstract

AIM

To investigate the expression of co-stimulatory molecule B7-H3 in gastric carcinoma and adenoma tissue as well as normal gastric tissue and to explore the relationship between B7-H3 expression and pathological features and prognosis of gastric carcinoma.

METHODS

B7-H3 expression was detected in 102 samples of human gastric carcinoma and 10 samples of gastric adenoma and 10 samples of normal gastric tissue by immunohistochemical assay. Correlation between the expression of B7-H3 and the patients' age, sex, gastric carcinoma locus, tumor size, tissue type, tumor infiltration depth, differentiation degree, lymph node metastasis, and survival time was analyzed.

RESULTS

B7-H3 was expressed in all gastric adenoma samples and in 58.8% samples of gastric carcinoma. B7-H3 expression in gastric carcinoma samples was not related with the patients' age, sex, lymph node metastasis, and tumor size (P>0.05), but with the survival time, infiltration depth of tumor and tissue type.

CONCLUSION

Detection of B7-H3 expression in gastric carcinoma tissue is beneficial to the judgment of the prognosis of gastric carcinoma patients and the choice of treatment.

摘要

目的

研究共刺激分子B7-H3在胃癌、胃腺瘤组织及正常胃组织中的表达情况，探讨B7-H3表达与胃癌病理特征及预后的关系。

方法

采用免疫组织化学法检测102例人胃癌组织、10例胃腺瘤组织及10例正常胃组织中B7-H3的表达。分析B7-H3表达与患者年龄、性别、胃癌部位、肿瘤大小、组织类型、肿瘤浸润深度、分化程度、淋巴结转移及生存时间的相关性。

结果

B7-H3在所有胃腺瘤组织样本及58.8%的胃癌组织样本中表达。胃癌组织样本中B7-H3的表达与患者年龄、性别、淋巴结转移及肿瘤大小无关（P>0.05），但与生存时间、肿瘤浸润深度及组织类型有关。

结论

检测胃癌组织中B7-H3的表达有助于判断胃癌患者的预后及治疗方案的选择。