Butkovic Diana, Toljan Sanja, Mihovilovic-Novak Beata
Department of Anaesthesiology, Reanimation and Intensive Care, Children's Hospital Zagreb, Klaiceva, Zagreb, Croatia.
Paediatr Anaesth. 2006 Mar;16(3):325-9. doi: 10.1111/j.1460-9592.2005.01687.x.
Summary Gabapentin is an antiepileptic drug indicated for the treatment of partial seizures in children. Many studies have proved its analgesic action in the treatment of neuropathic pain in adults and we have noticed an analgesic action of gabapentin in neuropathic pain in children. Five patients treated in the Children's Hospital Pain Control Service for intractable neuropathic pain were included in gabapentin treatment. Four were cancer patients and one suffered from neuropathic pain in the neck (C3). The visual analog scale (VAS) scores of pain were compared before and during treatment with gabapentin. We noticed a rapid improvement, in 1 week, of our patients' VAS scores (from 9 or 10 to 4 or 3) with minimal adverse effects. In the follow-up period of 6 months we gradually reduced the dose of gabapentin. Our findings are that gabapentin should be included earlier in the treatment of neuropathic pain in adolescents, because it rapidly improves analgesia and has minimal side effects.
加巴喷丁是一种抗癫痫药物，适用于治疗儿童部分性癫痫发作。许多研究已证实其在治疗成人神经性疼痛方面的镇痛作用，并且我们注意到加巴喷丁在儿童神经性疼痛中也有镇痛作用。儿童医院疼痛控制服务中心收治的5例顽固性神经性疼痛患儿接受了加巴喷丁治疗。其中4例为癌症患者，1例患有颈部（C3）神经性疼痛。比较了加巴喷丁治疗前后患者的视觉模拟评分（VAS）疼痛评分。我们注意到患者的VAS评分在1周内迅速改善（从9或10降至4或3），且不良反应极小。在6个月的随访期内，我们逐渐减少了加巴喷丁的剂量。我们的研究结果是，加巴喷丁应更早地用于青少年神经性疼痛的治疗，因为它能迅速改善镇痛效果且副作用极小。
