小儿胰腺炎
Paediatric pancreatitis.
作者信息
Pohl John F, Uc Aliye
机构信息
aDepartment of Pediatric Gastroenterology, Primary Children's Hospital, University of Utah School of Medicine, Salt Lake City, Utah bDepartment of Pediatric Gastroenterology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
出版信息
Curr Opin Gastroenterol. 2015 Sep;31(5):380-6. doi: 10.1097/MOG.0000000000000197.
PURPOSE OF REVIEW
The purpose of this review is to describe recent developments in paediatric pancreatitis and to discuss causes and current management.
RECENT FINDINGS
Although recent studies have estimated the annual incidence of paediatric acute pancreatitis approaching that of adults, there are no established guidelines about its diagnosis and treatment in children. Genetic and structural/congenital abnormalities are emerging as the primary risk factors for paediatric acute recurrent and chronic pancreatitis. Specifically, chronic pancreatitis is associated with a significant socioeconomic burden in children. Both medical and surgical therapies are proposed for paediatric chronic pancreatitis, but there is little evidence that they are beneficial.
SUMMARY
Acute recurrent and chronic pancreatitis create significant health issues in the paediatric population. Medical and surgical therapies exist to potentially treat these conditions, but the paediatric data are limited and the cohorts are small. A multidisciplinary and multicentre approach is necessary to better determine pancreatic disease processes and treatment options in children.
综述目的
本综述旨在描述小儿胰腺炎的最新进展，并讨论其病因及当前的治疗方法。
最新发现
尽管近期研究估计小儿急性胰腺炎的年发病率接近成人，但目前尚无关于小儿胰腺炎诊断和治疗的既定指南。遗传及结构/先天性异常正逐渐成为小儿急性复发性胰腺炎和慢性胰腺炎的主要危险因素。具体而言，慢性胰腺炎给儿童带来了巨大的社会经济负担。小儿慢性胰腺炎的治疗方案包括内科治疗和外科治疗，但几乎没有证据表明这些治疗方法有益。
总结
急性复发性胰腺炎和慢性胰腺炎给儿童群体带来了重大的健康问题。现有内科和外科治疗方法可能用于治疗这些疾病，但小儿相关数据有限且队列规模较小。需要采用多学科、多中心的方法，以更好地确定儿童胰腺疾病的发病过程及治疗方案。
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