Bachmann Martin F, Kopf Manfred, Marsland Benjamin J
Cytos Biotechnology AG, Wagistrasse 25, 8952 Zurich-Schlieren, Switzerland.
Nat Rev Immunol. 2006 Feb;6(2):159-64. doi: 10.1038/nri1776.
Chemokines have long been known to orchestrate dendritic-cell migration in the body. However, recent evidence has shown that chemokines not only direct the trafficking of dendritic cells but also can regulate their maturation status. Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming.
长期以来，人们一直认为趋化因子在体内协调树突状细胞的迁移。然而，最近的证据表明，趋化因子不仅指导树突状细胞的运输，还能调节它们的成熟状态。在此，我们提出趋化因子的这种双重功能确保了T细胞和树突状细胞在淋巴器官的T细胞区域相遇，并且抗原在免疫最佳的环境中呈递给T细胞以启动免疫反应。
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