Vincent Michael S, Leslie David S, Gumperz Jenny E, Xiong Xiaowei, Grant Ethan P, Brenner Michael B
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA.
Nat Immunol. 2002 Dec;3(12):1163-8. doi: 10.1038/ni851. Epub 2002 Nov 4.
Both microbial products and T cell factors influence dendritic cell (DC) maturation. However, it is not known which T cells are capable of interacting with DCs at the initiation of adaptive immunity, when foreign antigen-specific T cells are rare. We show here that self-reactive CD1-restricted T cells can promote DC maturation by recognizing CD1 in the absence of foreign antigens. T cell recognition of all four CD1 isoforms can trigger DC maturation, but their distinct mechanisms of costimulation lead to profound differences in concomitant interleukin 12 p70 production. Distinct CD1-reactive T cells may thus differentially direct DC development early in the immune response, thereby controlling subsequent polarization of acquired immunity.
微生物产物和T细胞因子均可影响树突状细胞（DC）的成熟。然而，在适应性免疫启动时，当外来抗原特异性T细胞数量稀少时，究竟哪些T细胞能够与DC相互作用尚不清楚。我们在此表明，自身反应性CD1限制性T细胞能够在无外来抗原的情况下通过识别CD1来促进DC成熟。对所有四种CD1异构体的T细胞识别均可触发DC成熟，但其不同的共刺激机制会导致伴随的白细胞介素12 p70产生存在显著差异。因此，不同的CD1反应性T细胞可能在免疫反应早期以不同方式指导DC的发育，从而控制获得性免疫随后的极化。
