Xia Guoyao, Yamamoto Hisashi
Department of Chemistry, The University of Chicago, Illinois 60637, USA.
J Am Chem Soc. 2006 Mar 1;128(8):2554-5. doi: 10.1021/ja058454p.
The utility of the new class of chiral ligand, tethered bis(8-quinolinol) (TBOxH), is further explored. Its chromium complex, TBOxCr(III)Cl, effectively catalyzes the Nozaki-Hiyama allylation reactions of various aldehydes at room temperature with high yield (up to 95%) and high enantioselectivity (up to 99% ee). The scope of the present method is shown to be wide, and this method represents an efficient access to chiral homoallylic alcohols.
新型手性配体 tethered bis(8 - 喹啉醇)(TBOxH) 的效用得到了进一步探索。其铬配合物 TBOxCr(III)Cl 在室温下能有效催化各种醛的野依良治 - 日山烯丙基化反应，产率高（高达 95%）且对映选择性高（高达 99% ee）。该方法的适用范围很广，是一种获得手性高烯丙醇的有效途径。
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