Kumbhar Sharad V, Chen Chinpiao
Department of Chemistry, National Dong Hwa University Shoufeng Hualien 974 Taiwan
Department of Nursing, Tzu Chi University of Science and Technology Hualien 970 Taiwan.
RSC Adv. 2018 Dec 12;8(72):41355-41357. doi: 10.1039/c8ra09575b. eCollection 2018 Dec 7.
We report the synthesis of bipyridyl ligands and these ligands were applied in the chromium-catalyzed enantioselective Nozaki-Hiyama-Kishi allylation of substituted (2-ethoxycarbonyl)benzaldehydes and subsequently lactonized to synthesize phthalides with an optimal enantioselectivity of 99%. This approach was applied to synthesize ()-cytosporone E at a 71% yield in three steps.
我们报道了联吡啶配体的合成，并将这些配体应用于铬催化的取代（2-乙氧羰基）苯甲醛的对映选择性野崎-桧山-岸烯丙基化反应，随后进行内酯化反应以合成对映选择性最佳可达99%的苯酞。该方法被用于三步合成（）-环孢菌素E，产率为71%。
