• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Chromatin remodeling by nucleosome disassembly in vitro.体外通过核小体解聚进行染色质重塑。
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3090-3. doi: 10.1073/pnas.0511050103. Epub 2006 Feb 21.
2
Coordinated Action of Nap1 and RSC in Disassembly of Tandem Nucleosomes.Nap1和RSC在串联核小体解聚中的协同作用。
Mol Cell Biol. 2016 Aug 12;36(17):2262-71. doi: 10.1128/MCB.00195-16. Print 2016 Sep 1.
3
p300-mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone.p300介导的乙酰化作用促进组蛋白H2A-H2B二聚体从核小体向一种组蛋白伴侣的转移。
Genes Dev. 2000 Aug 1;14(15):1899-907.
4
Removal of promoter nucleosomes by disassembly rather than sliding in vivo.在体内通过拆卸而非滑动来去除启动子核小体。
Mol Cell. 2004 Jun 4;14(5):667-73. doi: 10.1016/j.molcel.2004.05.013.
5
An Assay for Measuring Histone Variant Exchange within Nucleosomes In Vitro.一种体外测量核小体内组蛋白变体交换的检测方法。
Methods Mol Biol. 2017;1528:19-37. doi: 10.1007/978-1-4939-6630-1_2.
6
Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I.人类核小体组装蛋白I介导的含组蛋白变体的核小体核心颗粒的组装与拆卸
Mol Cell Biol. 2005 Dec;25(23):10639-51. doi: 10.1128/MCB.25.23.10639-10651.2005.
7
Nucleosome dynamics during chromatin remodeling in vivo.体内染色质重塑过程中的核小体动力学
Nucleus. 2016;7(1):20-6. doi: 10.1080/19491034.2016.1149666. Epub 2016 Mar 2.
8
Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.由组蛋白伴侣Asf1介导的染色质解聚对于酵母PHO5和PHO8基因的转录激活至关重要。
Mol Cell. 2004 Jun 4;14(5):657-66. doi: 10.1016/j.molcel.2004.05.016.
9
The synergy between RSC, Nap1 and adjacent nucleosome in nucleosome remodeling.核小体重塑中 RSC、Nap1 和相邻核小体之间的协同作用。
Biochim Biophys Acta Gene Regul Mech. 2019 Feb;1862(2):129-140. doi: 10.1016/j.bbagrm.2018.11.008. Epub 2018 Dec 26.
10
Nucleosome assembly and disassembly activity of GRWD1, a novel Cdt1-binding protein that promotes pre-replication complex formation.GRWD1的核小体组装与拆卸活性，一种促进复制前复合体形成的新型Cdt1结合蛋白。
Biochim Biophys Acta. 2016 Nov;1863(11):2739-2748. doi: 10.1016/j.bbamcr.2016.08.008. Epub 2016 Aug 20.

引用本文的文献

1
Integrated Single-cell Multiomic Analysis of HIV Latency Reversal Reveals Novel Regulators of Viral Reactivation.整合单细胞多组学分析 HIV 潜伏逆转揭示了病毒激活的新调控因子。
Genomics Proteomics Bioinformatics. 2024 May 9;22(1). doi: 10.1093/gpbjnl/qzae003.
2
Poly(dA:dT) Tracts Differentially Modulate Nucleosome Remodeling Activity of RSC and ISW1a Complexes, Exerting Tract Orientation-Dependent and -Independent Effects.多聚(dA:dT)序列区差异调节 RSC 和 ISW1a 复合物的核小体重塑活性，发挥序列区取向依赖和非依赖效应。
Int J Mol Sci. 2023 Oct 17;24(20):15245. doi: 10.3390/ijms242015245.
3
Histone chaperone Nap1 dismantles an H2A/H2B dimer from a partially unwrapped nucleosome.组蛋白伴侣 Nap1 从部分展开的核小体中拆除 H2A/H2B 二聚体。
Nucleic Acids Res. 2023 Jun 23;51(11):5351-5363. doi: 10.1093/nar/gkad396.
4
Role of the histone tails in histone octamer transfer.组蛋白尾部在组蛋白八聚体转移中的作用。
Nucleic Acids Res. 2023 May 8;51(8):3671-3678. doi: 10.1093/nar/gkad079.
5
Partitioned usage of chromatin remodelers by nucleosome-displacing factors.核小体移位因子对染色质重塑因子的分区使用。
Cell Rep. 2022 Aug 23;40(8):111250. doi: 10.1016/j.celrep.2022.111250.
6
Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer.染色质与染色质重塑体之间的复杂对话，以及癌症中的不和谐。
Int J Mol Sci. 2021 May 25;22(11):5578. doi: 10.3390/ijms22115578.
7
Distinct roles for RSC and SWI/SNF chromatin remodelers in genomic excision repair.RSC 和 SWI/SNF 染色质重塑因子在基因组切除修复中的不同作用。
Genome Res. 2021 Jun;31(6):1047-1059. doi: 10.1101/gr.274373.120. Epub 2021 May 17.
8
COMMD4 functions with the histone H2A-H2B dimer for the timely repair of DNA double-strand breaks.COMMD4 与组蛋白 H2A-H2B 二聚体一起作用，以实现 DNA 双链断裂的及时修复。
Commun Biol. 2021 Apr 19;4(1):484. doi: 10.1038/s42003-021-01998-2.
9
Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in .PBAP 染色质重塑因子的亚基能够介导. 中的增强子驱动的转录。
Int J Mol Sci. 2021 Mar 11;22(6):2856. doi: 10.3390/ijms22062856.
10
Chromatin Remodelers in the 3D Nuclear Compartment.三维核区室中的染色质重塑因子
Front Genet. 2020 Nov 3;11:600615. doi: 10.3389/fgene.2020.600615. eCollection 2020.

本文引用的文献

1
Histone release during transcription: displacement of the two H2A-H2B dimers in the nucleosome is dependent on different levels of transcription-induced positive stress.转录过程中的组蛋白释放：核小体中两个H2A-H2B二聚体的置换取决于转录诱导的正应力的不同水平。
Biochemistry. 2005 Apr 12;44(14):5357-72. doi: 10.1021/bi047786o.
2
Structural basis of eukaryotic gene transcription.真核基因转录的结构基础。
FEBS Lett. 2005 Feb 7;579(4):899-903. doi: 10.1016/j.febslet.2004.11.027.
3
Chromatin remodeling by DNA bending, not twisting.通过DNA弯曲而非扭转进行染色质重塑。
Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1329-32. doi: 10.1073/pnas.0409413102. Epub 2005 Jan 26.
4
Human Asf1 regulates the flow of S phase histones during replicational stress.人类Asf1在复制应激期间调节S期组蛋白的流动。
Mol Cell. 2005 Jan 21;17(2):301-11. doi: 10.1016/j.molcel.2004.12.018.
5
The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase.组蛋白伴侣抗沉默功能1是一种不依赖于S期进程的转录全局调节因子。
Mol Cell Biol. 2005 Jan;25(2):652-60. doi: 10.1128/MCB.25.2.652-660.2005.
6
Removal of promoter nucleosomes by disassembly rather than sliding in vivo.在体内通过拆卸而非滑动来去除启动子核小体。
Mol Cell. 2004 Jun 4;14(5):667-73. doi: 10.1016/j.molcel.2004.05.013.
7
Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.由组蛋白伴侣Asf1介导的染色质解聚对于酵母PHO5和PHO8基因的转录激活至关重要。
Mol Cell. 2004 Jun 4;14(5):657-66. doi: 10.1016/j.molcel.2004.05.016.
8
The absence of the yeast chromatin assembly factor Asf1 increases genomic instability and sister chromatid exchange.酵母染色质组装因子Asf1的缺失会增加基因组不稳定性和姐妹染色单体交换。
EMBO Rep. 2004 May;5(5):497-502. doi: 10.1038/sj.embor.7400128. Epub 2004 Apr 8.
9
DNA translocation and nucleosome remodeling assays by the RSC chromatin remodeling complex.通过RSC染色质重塑复合物进行的DNA易位和核小体重塑分析。
Methods Enzymol. 2004;377:322-43. doi: 10.1016/S0076-6879(03)77020-7.
10
Isolation and assay of the RSC chromatin-remodeling complex from Saccharomyces cerevisiae.从酿酒酵母中分离和测定RSC染色质重塑复合物
Methods Enzymol. 2004;377:316-22. doi: 10.1016/S0076-6879(03)77019-0.

体外通过核小体解聚进行染色质重塑。

Chromatin remodeling by nucleosome disassembly in vitro.

作者信息

Lorch Yahli, Maier-Davis Barbara, Kornberg Roger D

机构信息

Department of Structural Biology, Stanford University School of Medicine, CA 94305-5126, USA.

出版信息

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3090-3. doi: 10.1073/pnas.0511050103. Epub 2006 Feb 21.

DOI:10.1073/pnas.0511050103
PMID:16492771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1413907/
Abstract

The RSC chromatin-remodeling complex completely disassembles a nucleosome in the presence of the histone chaperone Nap1 and ATP. Disassembly occurs in a stepwise manner, with the removal of H2A/H2B dimers, followed by the rest of the histones and the release of naked DNA. RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo.

摘要

在组蛋白伴侣Nap1和ATP存在的情况下，RSC染色质重塑复合物可完全拆解一个核小体。拆解过程是逐步进行的，先是去除H2A/H2B二聚体，接着是其余组蛋白，最后释放出裸露的DNA。RSC及相关染色质重塑复合物可能负责体内转录激活过程中启动子核小体的去除。