Xiang Xin
Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
J Cell Biol. 2006 Feb 27;172(5):651-4. doi: 10.1083/jcb.200511081. Epub 2006 Feb 21.
Is there a cellular mechanism for preventing a depolymerizing microtubule track from "slipping out from under" its cargo? A recent study in budding yeast indicates that when a chromosome is transported to the minus end of a spindle microtubule, its kinetochore-bound microtubule plus end-tracking protein (+TIP) Stu2 may move to the plus end to promote rescue; i.e., to switch the depolymerizing end to a polymerizing end. The possibility that other +TIPs may play a similar role in sustaining a microtubule track during vesicular transport deserves investigation.
是否存在一种细胞机制来防止解聚的微管轨道从其货物“下方滑出”?最近一项对芽殖酵母的研究表明,当一条染色体被运输到纺锤体微管的负端时,其与动粒结合的微管正端追踪蛋白(+TIP)Stu2可能会移动到正端以促进拯救;也就是说,将解聚端转换为聚合端。其他+TIPs在囊泡运输过程中维持微管轨道方面可能发挥类似作用,这一可能性值得研究。