Vincent J L, Habib A M, Verdant C, Bruhn A
Deparment of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium.
Minerva Anestesiol. 2006 Mar;72(3):87-96.
Severe sepsis is a common disease process in the critically ill and is associated with substantial morbidity and mortality. Continuing research has provided considerable insight into the pathophysiology of sepsis over recent years, enabling various aspects of the sepsis response to be targeted. Discoveries related to the link between coagulation and inflammation have been particularly exciting, leading to the development of recombinant activated protein C. This review will discuss current definitions of sepsis, describe new approaches to classification and diagnosis of patients with sepsis, present recommendations for management, and briefly highlight areas of ongoing and future research.
严重脓毒症是危重症患者常见的疾病过程，与高发病率和死亡率相关。近年来，持续的研究为脓毒症的病理生理学提供了相当多的见解，使得脓毒症反应的各个方面都能成为治疗靶点。与凝血和炎症之间联系相关的发现尤其令人兴奋，促成了重组活化蛋白C的研发。本综述将讨论脓毒症的当前定义，描述脓毒症患者分类和诊断的新方法，提出管理建议，并简要强调正在进行和未来研究的领域。
