Departments of Clinical Neurological Sciences and Medicine, The University of Western Ontario, London, Ontario, Canada.
Crit Care. 2010;14(3):159. doi: 10.1186/cc9010. Epub 2010 May 21.
Sepsis-associated encephalopathy (SAE) resembles metabolic encephalopathies but with a difference: there is the potential for enduring brain damage/dysfunction. The pathogenesis of SAE is likely multifactorial. However, the severity of SAE parallels the severity of the septic illness and the brain's microcirculation is probably affected in a similar manner to that of other organs. Mild cases of SAE are often completely reversible, but there is increasing evidence that severe cases have neurological sequelae. A better understanding of the mechanisms may lead to brain-sparing, protective strategies.
脓毒症相关性脑病（SAE）类似于代谢性脑病，但有一个区别：它有可能导致持久的脑损伤/功能障碍。SAE 的发病机制可能是多因素的。然而，SAE 的严重程度与脓毒症的严重程度平行，大脑的微循环可能以类似于其他器官的方式受到影响。SAE 的轻度病例通常是完全可逆的，但越来越多的证据表明严重病例有神经后遗症。更好地了解这些机制可能会导致脑保护策略。
