网格蛋白衣被的生命周期：来自网格蛋白和衔接蛋白结构的见解

Life of a clathrin coat: insights from clathrin and AP structures.

作者信息

Edeling Melissa A, Smith Corinne, Owen David

机构信息

Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Hills Road, Cambridge, CB2 2XY, UK.

出版信息

Nat Rev Mol Cell Biol. 2006 Jan;7(1):32-44. doi: 10.1038/nrm1786.

DOI:10.1038/nrm1786

PMID:16493411

Abstract

Membrane sorting between secretory and endocytic organelles is predominantly controlled by small carrier vesicles or tubules that have specific protein coats on their cytoplasmic surfaces. Clathrin-clathrin-adaptor coats function in many steps of intracellular transport and are the most extensively studied of all transport-vesicle coats. In recent years, the determination of structures of clathrin assemblies by electron microscopy, of domains of clathrin and of its adaptors has improved our understanding of the molecular mechanisms of clathrin-coated-vesicle assembly and disassembly.

摘要

分泌细胞器和内吞细胞器之间的膜分选主要由小的载体囊泡或小管控制，这些囊泡或小管在其细胞质表面具有特定的蛋白质衣被。网格蛋白-网格蛋白衔接蛋白衣被在细胞内运输的许多步骤中发挥作用，是所有运输囊泡衣被中研究最为广泛的。近年来，通过电子显微镜对网格蛋白组装体结构、网格蛋白及其衔接蛋白结构域的测定，加深了我们对网格蛋白包被囊泡组装和解聚分子机制的理解。