Pley U, Parham P
Department of Microbiology and Immunology, Stanford University, School of Medicine, CA 94305.
Crit Rev Biochem Mol Biol. 1993;28(5):431-64. doi: 10.3109/10409239309078441.
Clathrin constitutes the coat of vesicles involved in three receptor-mediated intracellular transport pathways; the export of aggregated material from the trans-Golgi network for regulated secretion, the transfer of lysosomal hydrolases from the trans-Golgi network to lysosomes and receptor-mediated endocytosis at the plasma membrane. The clathrin subunits and the other major coat constituents, the adaptor polypeptides, interact in specific ways to build the characteristic polygonal clathrin lattice and to attach the coat to integral membrane receptors. Both clathrin coat assembly and disassembly on the cytoplasmic side of the membrane are multistep processes that are regulated by the coat constituents themselves and by cytosolic proteins and factors. Neurons represent a cell type with distinct morphology and special demands on exocytic and endocytic pathways that requires neuron-specific constituents and modifications of clathrin-coated vesicles.
网格蛋白构成了参与三种受体介导的细胞内运输途径的囊泡衣被；从反式高尔基体网络输出聚集物质以进行调节性分泌、将溶酶体水解酶从反式高尔基体网络转运到溶酶体以及在质膜上进行受体介导的内吞作用。网格蛋白亚基和其他主要衣被成分，即衔接蛋白多肽，以特定方式相互作用，构建特征性的多边形网格蛋白晶格，并将衣被附着于整合膜受体。膜细胞质侧的网格蛋白衣被组装和解聚都是多步骤过程，受衣被成分本身以及胞质蛋白和因子的调控。神经元是一种具有独特形态且对胞吐和胞吞途径有特殊需求的细胞类型，这需要神经元特异性成分以及对网格蛋白包被囊泡的修饰。
