一名使用实验性抗癌药物曲拉滨的葡萄糖-6-磷酸脱氢酶（G6PD）缺乏患者中亚硝酸盐血红蛋白血症和溶血的识别与管理
Recognition and management of methemoglobinemia and hemolysis in a G6PD-deficient patient on experimental anticancer drug Triapine.
作者信息
Foltz Lynda M, Dalal Bakul I, Wadsworth Louis D, Broady Raewyn, Chi Kim, Eisenhauer Elizabeth, Kobayashi Ken, Kollmannsburger Christian
机构信息
Division of Hematology, Vancouver General Hospital, Vancouver, British Columbia, Canada.
出版信息
Am J Hematol. 2006 Mar;81(3):210-1. doi: 10.1002/ajh.20547.
PMID:16493607
Abstract
We report occurrence of severe methemoglobinemia in a patient on novel experimental anti-cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high-risk populations prior to commencement of Triapine therapy.
摘要
我们报告了一名使用新型实验性抗癌药物曲拉滨的患者发生严重高铁血红蛋白血症的情况。由于同时存在葡萄糖-6-磷酸脱氢酶（G6PD）缺乏，亚甲蓝治疗导致了大量溶血。我们建议在开始曲拉滨治疗前，对高危人群进行G6PD筛查。
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