• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名使用实验性抗癌药物曲拉滨的葡萄糖-6-磷酸脱氢酶（G6PD）缺乏患者中亚硝酸盐血红蛋白血症和溶血的识别与管理

Recognition and management of methemoglobinemia and hemolysis in a G6PD-deficient patient on experimental anticancer drug Triapine.

作者信息

Foltz Lynda M, Dalal Bakul I, Wadsworth Louis D, Broady Raewyn, Chi Kim, Eisenhauer Elizabeth, Kobayashi Ken, Kollmannsburger Christian

机构信息

Division of Hematology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

出版信息

Am J Hematol. 2006 Mar;81(3):210-1. doi: 10.1002/ajh.20547.

DOI:10.1002/ajh.20547
PMID:16493607
Abstract

We report occurrence of severe methemoglobinemia in a patient on novel experimental anti-cancer drug, Triapine. Treatment with methylene blue led to massive hemolysis due to concomitant G6PD deficiency. We recommend that G6PD screening be done in high-risk populations prior to commencement of Triapine therapy.

摘要

我们报告了一名使用新型实验性抗癌药物曲拉滨的患者发生严重高铁血红蛋白血症的情况。由于同时存在葡萄糖-6-磷酸脱氢酶（G6PD）缺乏，亚甲蓝治疗导致了大量溶血。我们建议在开始曲拉滨治疗前，对高危人群进行G6PD筛查。

相似文献

1
Recognition and management of methemoglobinemia and hemolysis in a G6PD-deficient patient on experimental anticancer drug Triapine.一名使用实验性抗癌药物曲拉滨的葡萄糖-6-磷酸脱氢酶（G6PD）缺乏患者中亚硝酸盐血红蛋白血症和溶血的识别与管理
Am J Hematol. 2006 Mar;81(3):210-1. doi: 10.1002/ajh.20547.
2
Rediscovery of the susceptibility of G6PD deficient persons to methemoglobinemia from oxidant drugs, and to hemolysis from methylene blue.重新发现葡萄糖-6-磷酸脱氢酶（G6PD）缺乏者对氧化药物引起的高铁血红蛋白血症以及对亚甲蓝引起的溶血敏感。
Am J Hematol. 2007 Jan;82(1):87-8. doi: 10.1002/ajh.20704.
3
Drug-induced haemolysis and methaemoglobinaemia in glucose 6-phosphate dehydrogenase deficiency.葡萄糖-6-磷酸脱氢酶缺乏症中的药物性溶血和高铁血红蛋白血症
Br J Haematol. 2005 May;129(3):291. doi: 10.1111/j.1365-2141.2005.05404.x.
4
Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia.亚甲蓝治疗苯胺所致高铁血红蛋白血症后发生的溶血性贫血。
Vet Hum Toxicol. 2002 Feb;44(1):19-21.
5
Methemoglobinemia and hemolysis in a patient with G6PD deficiency treated with rasburicase.接受拉布立酶治疗的葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症患者出现高铁血红蛋白血症和溶血。
Am J Hematol. 2013 Feb;88(2):152-4. doi: 10.1002/ajh.23182. Epub 2012 May 10.
6
Acute hemolysis and methemoglobinemia secondary to fava beans ingestion in a patient with G6PD deficiency: A case report of a rare co-occurrence.患者进食蚕豆后发生急性溶血和高铁血红蛋白血症，伴葡萄糖-6-磷酸脱氢酶缺乏：一种罕见合并症的病例报告。
Medicine (Baltimore). 2021 Nov 24;100(47):e27904. doi: 10.1097/MD.0000000000027904.
7
Unsuspected glucose-6-phosphate dehydrogenase deficiency presenting as symptomatic methemoglobinemia with severe hemolysis after fava bean ingestion in a 6-year-old boy.6 岁男孩食用豇豆后出现症状性高铁血红蛋白血症伴严重溶血，葡萄糖-6-磷酸脱氢酶缺乏症未被发现。
Int J Hematol. 2011 May;93(5):664-666. doi: 10.1007/s12185-011-0827-6. Epub 2011 Apr 12.
8
Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.一位患有特发性荨麻疹的女性在无 G6PD 缺乏的情况下因使用氨苯砜引起高铁血红蛋白血症和溶血。
Hematology. 2022 Dec;27(1):1253-1258. doi: 10.1080/16078454.2022.2149943.
9
Rasburicase causing severe oxidative hemolysis and methemoglobinemia in a patient with previously unrecognized glucose-6-phosphate dehydrogenase deficiency.拉布立酶导致先前未被识别的葡萄糖-6-磷酸脱氢酶缺乏症患者发生严重氧化溶血和高铁血红蛋白血症。
Acta Haematol. 2013;130(4):254-9. doi: 10.1159/000351048. Epub 2013 Jul 11.
10
Mothball Ingestion in the Setting of G6PD Deficiency Causing Severe Hemolytic Anemia, Methemoglobinemia, and Multiple Organ Failure in a Toddler.婴儿摄入樟脑丸致 G6PD 缺乏症严重溶血性贫血、高铁血红蛋白血症和多器官功能衰竭
Hawaii J Health Soc Welf. 2022 Jan;81(1):3-5.

引用本文的文献

1
Dose finding, bioavailability, and PK-PD of oral triapine with concurrent chemoradiation for locally advanced cervical cancer and vaginal cancer (ETCTN 9892).口服曲拉扎明联合放化疗治疗局部晚期宫颈癌和阴道癌的剂量探索、生物利用度及药代动力学-药效学研究（ETCTN 9892）
Cancer Chemother Pharmacol. 2024 Dec 14;95(1):4. doi: 10.1007/s00280-024-04720-1.
2
8-Aminoquinoline Therapy for Latent Malaria.8-氨基喹啉疗法治疗潜伏疟疾。
Clin Microbiol Rev. 2019 Jul 31;32(4). doi: 10.1128/CMR.00011-19. Print 2019 Sep 18.
3
Improvement in Hemodynamics After Methylene Blue Administration in Drug-Induced Vasodilatory Shock: A Case Report.
亚甲蓝治疗药物性血管扩张性休克后血流动力学的改善：一例报告
J Med Toxicol. 2015 Dec;11(4):460-3. doi: 10.1007/s13181-015-0500-1.
4
G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications.葡萄糖-6-磷酸脱氢酶缺乏症：一个具有持续临床意义的经典药物遗传学范例。
Br J Haematol. 2014 Feb;164(4):469-80. doi: 10.1111/bjh.12665. Epub 2013 Dec 28.
5
PharmGKB summary: methylene blue pathway.药物基因组学知识库总结：亚甲蓝途径。
Pharmacogenet Genomics. 2013 Sep;23(9):498-508. doi: 10.1097/FPC.0b013e32836498f4.
6
Unsuspected glucose-6-phosphate dehydrogenase deficiency presenting as symptomatic methemoglobinemia with severe hemolysis after fava bean ingestion in a 6-year-old boy.6 岁男孩食用豇豆后出现症状性高铁血红蛋白血症伴严重溶血，葡萄糖-6-磷酸脱氢酶缺乏症未被发现。
Int J Hematol. 2011 May;93(5):664-666. doi: 10.1007/s12185-011-0827-6. Epub 2011 Apr 12.
7
Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancer.3-氨基吡啶-2-羧醛硫代半卡巴腙联合吉西他滨治疗晚期胆道癌的 II 期临床试验。
Cancer Chemother Pharmacol. 2011 Aug;68(2):379-88. doi: 10.1007/s00280-010-1481-z. Epub 2010 Oct 28.
8
Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review.药物与葡萄糖-6-磷酸脱氢酶缺乏：循证综述。
Drug Saf. 2010 Sep 1;33(9):713-26. doi: 10.2165/11536520-000000000-00000.
9
Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine®) in cancer patients.癌症患者中 3-氨基吡啶-2-甲酰基缩氨基硫脲（Triapine®）的群体药代动力学。
Cancer Chemother Pharmacol. 2011 Feb;67(2):393-400. doi: 10.1007/s00280-010-1331-z. Epub 2010 May 4.
10
The maximum tolerated dose and biologic effects of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) in combination with irinotecan for patients with refractory solid tumors.3-氨基吡啶-2-甲酰基缩氨基硫脲（3-AP）联合伊立替康治疗耐药实体瘤患者的最大耐受剂量和生物学效应。
Cancer Chemother Pharmacol. 2010 Oct;66(5):973-80. doi: 10.1007/s00280-010-1250-z. Epub 2010 Feb 2.