Pszenna Mirosława, Rokosz Alicja, Luczak Mirosław
Pracownia Bakteriologiczna Laboratorium Analiz Lekarskich SP ZOZ w Działdowie.
Med Dosw Mikrobiol. 2005;57(3):303-10.
The aim of this study was to evaluate a frequency of isolation and antimicrobial susceptibility testing (AST) of Pseudomonas aeruginosa strains cultured from clinical specimens collected from patients hospitalized in wards and specialistic outpatients clinics of a hospital in Nidzica (01. 09. 2000 -31. 12. 2003). During over three years 392 Pseudomonas aeruginosa strains were cultured from 16346 clinical samples provided to bacteriological laboratory. P. aeruginosa strains were isolated from 2.5% of examined specimens. Susceptibility of Pseudomonas aeruginosa strains to antimicrobial agents was tested. The highest in vitro activity against clinical P. aeruginosa strains demonstrated imipenem. One strain was resistant to imipenem. This strain was isolated from a patient of a surgical department. Metalo-beta-lactamase was not detected (MBL-negative strain). Twenty nine strains were ESBL producer (7.4% of all strains). The contribution of Pseudomonas aeruginosa strains to the etiology of nosoconial and ambulatory infections increases. In vitro activity of antibacterial agents against P. aeruginosa strains should be monitored during therapy of infections. Resistance to antibiotics/chemothe-rapeutics may be acquired during treatment with antibacterial agent to which P. aeruginosa strain was susceptible according to the antibiogram.
本研究的目的是评估从尼济察一家医院的病房和专科门诊住院患者采集的临床标本中培养出的铜绿假单胞菌菌株的分离频率和抗菌药物敏感性试验（AST）。在三年多的时间里，从提供给细菌学实验室的16346份临床样本中培养出392株铜绿假单胞菌菌株。铜绿假单胞菌菌株从2.5%的检测标本中分离出来。对铜绿假单胞菌菌株对抗菌药物的敏感性进行了测试。亚胺培南对临床铜绿假单胞菌菌株的体外活性最高。有一株对亚胺培南耐药。该菌株从一名外科患者中分离出来。未检测到金属β-内酰胺酶（MBL阴性菌株）。29株为超广谱β-内酰胺酶产生菌（占所有菌株的7.4%）。铜绿假单胞菌菌株在医院感染和门诊感染病因中的作用增加。在感染治疗期间，应监测抗菌药物对铜绿假单胞菌菌株的体外活性。根据抗菌谱，铜绿假单胞菌菌株对某种抗菌药物敏感，但在使用该抗菌药物治疗期间可能会获得对该药物（抗生素/化疗药物）的耐药性。
