（-）-N，N'-丁-2-烯-1,4-二基双吗啡喃类化合物。
(-)-N,N'-but-2-ene-1,4-diylbimorphinans.
作者信息
Schmidhammer H, Smith C F, Dalkner E, Erlach D, Heuberger M, Rollinger J M
机构信息
Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Austria.
出版信息
Pharmazie. 1991 Feb;46(2):101-2.
PMID:1649476
Abstract
N,N'-But-2-ene-1,4-diylbimorphinans 1-3 have been synthesized and pharmacologically evaluated. Bimorphinans 1 and 3 show opioid antagonist activity and preference for mu and kappa opioid receptors in mouse vas deferens and guinea pig ileum preparations.
摘要
已合成了N,N'-丁-2-烯-1,4-二亚基双吗啡喃类化合物1-3，并对其进行了药理学评估。双吗啡喃类化合物1和3在小鼠输精管和豚鼠回肠制剂中表现出阿片样物质拮抗剂活性，并对μ和κ阿片样物质受体具有选择性。
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