Simon Wolfgang Alexander, Sturm Ernst, Hartmann Hans-Jürgen, Weser Ulrich
ALTANA Pharma AG, Byk Guldenstrasse 2, D 78464 Konstanz, Germany.
Biochem Pharmacol. 2006 Apr 28;71(9):1337-41. doi: 10.1016/j.bcp.2006.01.009. Epub 2006 Feb 21.
In addition to the established control of acid secretion of the class of proton pump inhibitors (PPI) reactivity from the pyridyl methyl sulphinyl benzimidazole type a second independent anti-inflammatory reactivity was observed in vitro. This inhibitory reactivity was clearly noticed using three different assays where the aggressive hydroxyl radicals were successfully trapped in a concentration dependent manner. There is unequivocal evidence that the proton pump inhibitors having the sulphoxide group are able to scavenge hydroxyl radicals which are generated during a Fenton reaction. By way of contrast, the corresponding thioethers were substantially less active. No detectable effect was seen in the superoxide radical scavenging system. In conclusion, pantoprazole as well as the other proton pump inhibitors have a pronounced inhibitory reactivity towards hydroxyl radicals.
除了已确定的质子泵抑制剂（PPI）类对吡啶基甲基亚磺酰基苯并咪唑型酸分泌的控制作用外，体外还观察到了第二种独立的抗炎反应性。使用三种不同的测定方法清楚地观察到了这种抑制反应性，在这些方法中，活性羟基自由基以浓度依赖的方式被成功捕获。有明确证据表明，具有亚砜基团的质子泵抑制剂能够清除芬顿反应过程中产生的羟基自由基。相比之下，相应的硫醚活性则低得多。在超氧自由基清除系统中未观察到可检测的效果。总之，泮托拉唑以及其他质子泵抑制剂对羟基自由基具有显著的抑制反应性。
