Truong-Bolduc Que Chi, Strahilevitz Jacob, Hooper David C
Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston Massachusetts 02114-2696, USA.
Antimicrob Agents Chemother. 2006 Mar;50(3):1104-7. doi: 10.1128/AAC.50.3.1104-1107.2006.
NorC, a new efflux pump, like NorB, contributes to quinolone resistance that includes resistance to moxifloxacin and sparfloxacin in Staphylococcus aureus. norC expression, like that of norB and tet38, is negatively regulated by MgrA, and overexpression of both norC and norB contributes to the quinolone resistance phenotype of an mgrA mutant.
NorC是一种新的外排泵，与NorB一样，会导致金黄色葡萄球菌对喹诺酮类药物产生耐药性，包括对莫西沙星和司帕沙星的耐药性。与norB和tet38一样，norC的表达受MgrA负调控，norC和norB的过表达均会导致mgrA突变体出现喹诺酮耐药表型。
