Ihara T, Kato T, Torigoe S, Oitani K, Isaji M, Ito M, Kamiya H, Sakura M
Department of Pediatrics, Mie National Hospital, Japan.
Acta Paediatr Jpn. 1991 Feb;33(1):43-9. doi: 10.1111/j.1442-200x.1991.tb01518.x.
Humoral and cellular immune responses were examined in 115 children with varicella and in 21 children who had been immunized with live varicella vaccine. Antibody determined with antibody-dependent cell-mediated cytotoxicity (ADCC) was detected earlier than neutralizing antibody (NT) in both groups. While humoral and cellular immunity were detected simultaneously in the natural varicella group, cellular immunity was detected earlier than humoral immunity in the immunized group. This suggests that ADCC, rather than NT, is involved in the early stages of recovery from varicella-zoster virus (VZV) infection.
对115名水痘患儿和21名接种过水痘减毒活疫苗的儿童进行了体液免疫和细胞免疫反应检测。在两组中，通过抗体依赖性细胞介导的细胞毒性（ADCC）检测到的抗体均早于中和抗体（NT）。在自然感染水痘组中，体液免疫和细胞免疫同时被检测到，而在免疫组中，细胞免疫比体液免疫更早被检测到。这表明ADCC而非NT参与了水痘-带状疱疹病毒（VZV）感染恢复的早期阶段。
