Shiraki K, Yamanishi K, Takahashi M, Dohi Y
Biken J. 1984 Mar;27(1):19-22.
The relation of delayed type hypersensitivity (DTH) assessed by the Varicella-Zoster virus (VZV) skin test and lymphocyte transformation (LTF) with VZV antigen was investigated in guinea pigs immunized with live varicella vaccine virus, or heat-inactivated vaccine virus. Guinea pigs immunized with live varicella vaccine virus showed positive DTH and LTF responses to viral antigen as well as a neutralizing (NT) antibody response, while those immunized with heat-inactivated vaccine virus showed only an NT antibody response of the same degree as that to live vaccine virus. These results show the reliability of the skin test in assessing cell-mediated immunity (CMI) to VZV and the advantage of the live varicella vaccine over the inactivated one in immunizing guinea pigs.
在用活水痘疫苗病毒或热灭活疫苗病毒免疫的豚鼠中，研究了通过水痘 - 带状疱疹病毒（VZV）皮肤试验评估的迟发型超敏反应（DTH）以及淋巴细胞转化（LTF）与VZV抗原的关系。用活水痘疫苗病毒免疫的豚鼠对病毒抗原表现出阳性DTH和LTF反应以及中和（NT）抗体反应，而用热灭活疫苗病毒免疫的豚鼠仅表现出与活疫苗病毒相同程度的NT抗体反应。这些结果表明皮肤试验在评估对VZV的细胞介导免疫（CMI）方面的可靠性，以及活水痘疫苗在免疫豚鼠方面优于灭活疫苗的优势。
