Gillespie Neil D
Medicine (Ageing & Health), University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY, United Kingdom.
Br Med Bull. 2006 Feb 22;75-76:49-62. doi: 10.1093/bmb/ldh060. Print 2005.
Chronic heart failure is a common problem in old age. Dyspnoea and fatigue are the most common symptoms and should alert the clinician to the likely diagnosis. When there is a clinical suspicion of heart failure, further assessment is required to confirm the aetiology. In older patients, heart failure with normal systolic function is frequently encountered. However, patients with left ventricular systolic dysfunction usually have a poorer prognosis, and most treatments have been evaluated in these patients. Useful investigations include the 12-lead electrocardiogram, chest radiology and echocardiography. A blood test for B-type natriuretic peptide is being increasingly used as a 'rule out' test for heart failure. There are several treatment options. Initially, patients should be treated with a diuretic and ACE inhibitor, provided there are no contraindications. beta-Blocker therapy is also first-line therapy once a patients' haemodynamic status has been stabilized. Additional treatments include spironolactone, angiotensin antagonists and digoxin. Patient factors and tolerability may limit the number of treatment options. Treatment regimes are most effective when delivered using a multidisciplinary approach.
慢性心力衰竭是老年人常见的问题。呼吸困难和乏力是最常见的症状,应提醒临床医生考虑可能的诊断。当临床上怀疑心力衰竭时,需要进一步评估以确定病因。在老年患者中,经常会遇到收缩功能正常的心力衰竭。然而,左心室收缩功能障碍的患者通常预后较差,并且大多数治疗方法已经在这些患者中进行了评估。有用的检查包括12导联心电图、胸部放射学检查和超声心动图检查。检测B型利钠肽的血液检查越来越多地被用作心力衰竭的“排除”检查。有几种治疗选择。最初,只要没有禁忌症,患者应接受利尿剂和血管紧张素转换酶抑制剂治疗。一旦患者的血流动力学状态稳定,β受体阻滞剂治疗也是一线治疗方法。其他治疗包括螺内酯、血管紧张素拮抗剂和地高辛。患者因素和耐受性可能会限制治疗选择的数量。采用多学科方法实施治疗方案时最为有效。