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齿垢密螺旋体主要外鞘蛋白对人中性粒细胞功能的体外调节

Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein.

作者信息

Puthengady Thomas Bina, Sun Chun Xiang, Bajenova Elena, Ellen Richard P, Glogauer Michael

机构信息

CIHR Group in Matrix Dynamics and Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5S 3E2.

出版信息

Infect Immun. 2006 Mar;74(3):1954-7. doi: 10.1128/IAI.74.3.1954-1957.2006.

DOI:10.1128/IAI.74.3.1954-1957.2006
PMID:16495573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1418645/
Abstract

In this study of human polymorphonuclear leukocytes (PMNs), pretreatment with Treponema denticola major outer sheath protein (Msp) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, phagocytosis of immunoglobulin G-coated microspheres, fMLP-stimulated calcium transients, and actin assembly. Msp neither altered oxidative responses to phorbol myristate or fMLP nor induced apoptosis. Msp selectively impairs chemotaxis and phagocytosis by impacting the PMN cytoskeleton.

摘要

在这项针对人类多形核白细胞（PMNs）的研究中，用齿垢密螺旋体主要外鞘蛋白（Msp）进行预处理可抑制甲酰甲硫氨酰亮氨酰苯丙氨酸（fMLP）诱导的趋化作用、免疫球蛋白G包被微球的吞噬作用、fMLP刺激的钙瞬变以及肌动蛋白组装。Msp既不改变对佛波酯或fMLP的氧化反应，也不诱导细胞凋亡。Msp通过影响PMN细胞骨架选择性地损害趋化作用和吞噬作用。

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本文引用的文献

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Spirochetes at the forefront of periodontal infections.处于牙周感染前沿的螺旋体。
Periodontol 2000. 2005;38:13-32. doi: 10.1111/j.1600-0757.2005.00108.x.
2
Induction of de novo subcortical actin filament assembly by Treponema denticola major outer sheath protein.齿垢密螺旋体主要外鞘蛋白诱导新生皮质下肌动蛋白丝组装
Infect Immun. 2004 Jun;72(6):3650-4. doi: 10.1128/IAI.72.6.3650-3654.2004.
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The major outer sheath protein of Treponema denticola inhibits the binding step of collagen phagocytosis in fibroblasts.齿垢密螺旋体的主要外鞘蛋白抑制成纤维细胞中胶原吞噬作用的结合步骤。
Cell Microbiol. 2004 May;6(5):485-98. doi: 10.1111/j.1462-5822.2004.00377.x.
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Flow cytometry study of polymorphonuclear neutrophil oxidative burst: a comparison of three fluorescent probes.多形核中性粒细胞氧化爆发的流式细胞术研究：三种荧光探针的比较
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Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes.人多形核白细胞凋亡过程中促炎能力的下调。
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Role of Treponema denticola in periodontal diseases.齿垢密螺旋体在牙周疾病中的作用。
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Subgingival microbial profiles in refractory periodontal disease.难治性牙周病的龈下微生物图谱
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Mechanisms and modulation of formyl-methionyl-leucyl-phenylalanine (fMLP)-induced Ca2+ mobilization in human neutrophils.人中性粒细胞中N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（fMLP）诱导的Ca2+动员的机制及调节
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A spirochete surface protein uncouples store-operated calcium channels in fibroblasts: a novel cytotoxic mechanism.一种螺旋体表面蛋白可使成纤维细胞中的储存式钙通道解偶联：一种新的细胞毒性机制。
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