两性霉素B对巨噬细胞超氧阴离子生成的增强作用。
Enhancement of macrophage superoxide anion production by amphotericin B.
作者信息
Wilson E, Thorson L, Speert D P
机构信息
Division of Infectious Diseases, British Columbia's Children's Hospital, Vancouver, Canada.
出版信息
Antimicrob Agents Chemother. 1991 May;35(5):796-800. doi: 10.1128/AAC.35.5.796.
Abstract
Amphotericin B (AmB) appears to have some important immunomodulatory effects, but its mechanism of action has not been explained. We investigated the effects of AmB on activation of human monocyte-derived macrophages. Macrophages cultured in the presence of AmB had an enhanced capacity to produce superoxide anion after stimulation with phorbol myristate acetate. This enhancement was dose dependent within a therapeutic range of AmB levels (0.1 to 3.0 mg/liter). Macrophages cultured in the presence of AmB had enhanced surface expression of Ia antigen; phagocytosis of unopsonized zymosan, opsonized Staphylococcus aureus, or erythrocytes opsonized with C3bi or immunoglobulin G paradoxically appeared to be reduced, but results did not achieve statistical significance. AmB appears to activate macrophages and may do so via direct effects on the plasma membrane.
摘要
两性霉素B（AmB）似乎具有一些重要的免疫调节作用，但其作用机制尚未明确。我们研究了AmB对人单核细胞衍生巨噬细胞激活的影响。在AmB存在下培养的巨噬细胞在用佛波酯肉豆蔻酸酯刺激后产生超氧阴离子的能力增强。在AmB水平的治疗范围内（0.1至3.0毫克/升），这种增强呈剂量依赖性。在AmB存在下培养的巨噬细胞Ia抗原的表面表达增强；未调理的酵母聚糖、调理的金黄色葡萄球菌或用C3bi或免疫球蛋白G调理的红细胞的吞噬作用似乎反而降低，但结果未达到统计学意义。AmB似乎可激活巨噬细胞，且可能通过对质膜的直接作用来实现。
相似文献
1
Enhancement of macrophage superoxide anion production by amphotericin B.两性霉素B对巨噬细胞超氧阴离子生成的增强作用。
Antimicrob Agents Chemother. 1991 May;35(5):796-800. doi: 10.1128/AAC.35.5.796.
2
Production of superoxide anion by bovine pulmonary macrophages challenged with soluble and particulate stimuli.用可溶性和颗粒性刺激物刺激牛肺巨噬细胞产生超氧阴离子。
Am J Vet Res. 1985 Feb;46(2):336-41.
3
Increased superoxide anion production by immunologically activated and chemically elicited macrophages.免疫激活和化学诱导的巨噬细胞中超氧阴离子生成增加。
J Exp Med. 1978 Jul 1;148(1):115-27. doi: 10.1084/jem.148.1.115.
4
5
6
Suppression by human recombinant gamma interferon of in vitro macrophage nonopsonic and opsonic phagocytosis and killing.人重组γ干扰素对体外巨噬细胞非调理和调理吞噬及杀伤作用的抑制
Infect Immun. 1991 Jun;59(6):1893-8. doi: 10.1128/iai.59.6.1893-1898.1991.
7
Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production.蛋白激酶C对巨噬细胞超氧化物的产生既有刺激作用，又有抑制作用。
J Cell Physiol. 1992 Jul;152(1):64-70. doi: 10.1002/jcp.1041520109.
8
9
Factors which affect superoxide anion release from rat alveolar macrophages.
Exp Lung Res. 1981 May;2(2):85-96. doi: 10.3109/01902148109052305.
10
HIV-1-infected monocytes and monocyte-derived macrophages are impaired in their ability to produce superoxide radicals.感染HIV-1的单核细胞和单核细胞衍生的巨噬细胞产生超氧自由基的能力受损。
Int J Clin Lab Res. 1997;27(2):111-7. doi: 10.1007/BF02912444.
引用本文的文献
1
Repurposing Amphotericin B and Its Liposomal Formulation for the Treatment of Human Mpox.将两性霉素 B 及其脂质体制剂重新用于治疗人类猴痘。
Int J Mol Sci. 2023 May 17;24(10):8896. doi: 10.3390/ijms24108896.
2
Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications.多烯抗生素的物理化学性质及其对脂质膜的影响；对生物过程和医学应用的影响
Membranes (Basel). 2022 Jun 30;12(7):681. doi: 10.3390/membranes12070681.
3
Topical treatment with nanoliposomal Amphotericin B reduces early lesion growth but fails to induce cure in an experimental model of cutaneous leishmaniasis caused by Leishmania mexicana.用纳米脂质体两性霉素B进行局部治疗可减少早期病变的生长，但在墨西哥利什曼原虫引起的皮肤利什曼病实验模型中未能诱导治愈。
Acta Trop. 2017 Sep;173:102-108. doi: 10.1016/j.actatropica.2017.06.004. Epub 2017 Jun 9.
4
Evaluation of Hepatotoxicity with Treatment Doses of Flucytosine and Amphotericin B for Invasive Fungal Infections.使用氟胞嘧啶和两性霉素B治疗剂量对侵袭性真菌感染进行肝毒性评估。
Biomed Res Int. 2016;2016:5398730. doi: 10.1155/2016/5398730. Epub 2016 Feb 2.
5
Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells.治疗性激活巨噬细胞和小胶质细胞以抑制脑肿瘤起始细胞。
Nat Neurosci. 2014 Jan;17(1):46-55. doi: 10.1038/nn.3597. Epub 2013 Dec 8.
6
It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug.只需一种药物就能发挥多种作用：两性霉素B作为抗真菌和免疫调节药物。
Front Microbiol. 2012 Aug 8;3:286. doi: 10.3389/fmicb.2012.00286. eCollection 2012.
7
Optimizing efficacy of Amphotericin B through nanomodification.通过纳米修饰优化两性霉素B的疗效。
Int J Nanomedicine. 2007;2(3):301-13.
8
Effects of lipid formulations of amphotericin B on activity of human monocytes against Aspergillus fumigatus.两性霉素B脂质制剂对人单核细胞抗烟曲霉活性的影响。
Antimicrob Agents Chemother. 2006 Mar;50(3):868-73. doi: 10.1128/AAC.50.3.868-873.2006.
9
Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.两性霉素B对新型隐球菌在小鼠感染过程中荚膜和细胞大小的影响。
Antimicrob Agents Chemother. 2005 Oct;49(10):4358-61. doi: 10.1128/AAC.49.10.4358-4361.2005.
10
Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus.两性霉素B制剂与肺泡巨噬细胞和多形核白细胞联合使用时，对烟曲霉具有相加抗真菌活性。
Antimicrob Agents Chemother. 2002 Jun;46(6):1974-6. doi: 10.1128/AAC.46.6.1974-1976.2002.
本文引用的文献
1
The extinction coefficient of cytochrome c.细胞色素c的消光系数。
Biochim Biophys Acta. 1962 Apr 23;58:593-5. doi: 10.1016/0006-3002(62)90073-2.
2
Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes.促肿瘤佛波酯可刺激培养的人单核细胞中C3b和C3b'受体介导的吞噬作用。
J Exp Med. 1982 Oct 1;156(4):1149-64. doi: 10.1084/jem.156.4.1149.
3
Strategies in the treatment of systemic fungal infections.系统性真菌感染的治疗策略。
N Engl J Med. 1980 Jan 17;302(3):145-55. doi: 10.1056/NEJM198001173020304.
4
Intracellular parasites and phagocytic cells: cell biology and pathophysiology.
Rev Infect Dis. 1982 Jan-Feb;4(1):124-35. doi: 10.1093/clinids/4.1.124.
5
Stimulation of human and canine neutrophil metabolism by amphotericin B.两性霉素B对人和犬中性粒细胞代谢的刺激作用。
Antimicrob Agents Chemother. 1981 Feb;19(2):284-9. doi: 10.1128/AAC.19.2.284.
6
Ketoconazole, amphotericin B, and amphotericin B methyl ester: comparative in vitro and in vivo toxicological effects on neutrophil function.酮康唑、两性霉素B及两性霉素B甲酯：对中性粒细胞功能的体外及体内毒理学效应比较
Antimicrob Agents Chemother. 1981 Nov;20(5):660-5. doi: 10.1128/AAC.20.5.660.
7
Changes in murine resistance to Listeria monocytogenes infection induced by amphotericin B.
J Infect Dis. 1973 Apr;127(4):373-7. doi: 10.1093/infdis/127.4.373.
8
A new therapeutic approach to Candida infections. A preliminary report.
Arch Intern Med. 1972 Aug;130(2):241-5.
9
The effects of the polyene antibiotics nystatin and amphotericin B on thin lipid membranes.多烯抗生素制霉菌素和两性霉素B对薄脂质膜的作用。
Ann N Y Acad Sci. 1974 May 10;235(0):469-79. doi: 10.1111/j.1749-6632.1974.tb43284.x.
10
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.生物防御机制。白细胞产生超氧化物，一种潜在的杀菌剂。
J Clin Invest. 1973 Mar;52(3):741-4. doi: 10.1172/JCI107236.
Zotero 插件