Wilson E, Thorson L, Speert D P
Division of Infectious Diseases, British Columbia's Children's Hospital, Vancouver, Canada.
Antimicrob Agents Chemother. 1991 May;35(5):796-800. doi: 10.1128/AAC.35.5.796.
Amphotericin B (AmB) appears to have some important immunomodulatory effects, but its mechanism of action has not been explained. We investigated the effects of AmB on activation of human monocyte-derived macrophages. Macrophages cultured in the presence of AmB had an enhanced capacity to produce superoxide anion after stimulation with phorbol myristate acetate. This enhancement was dose dependent within a therapeutic range of AmB levels (0.1 to 3.0 mg/liter). Macrophages cultured in the presence of AmB had enhanced surface expression of Ia antigen; phagocytosis of unopsonized zymosan, opsonized Staphylococcus aureus, or erythrocytes opsonized with C3bi or immunoglobulin G paradoxically appeared to be reduced, but results did not achieve statistical significance. AmB appears to activate macrophages and may do so via direct effects on the plasma membrane.
两性霉素B（AmB）似乎具有一些重要的免疫调节作用，但其作用机制尚未明确。我们研究了AmB对人单核细胞衍生巨噬细胞激活的影响。在AmB存在下培养的巨噬细胞在用佛波酯肉豆蔻酸酯刺激后产生超氧阴离子的能力增强。在AmB水平的治疗范围内（0.1至3.0毫克/升），这种增强呈剂量依赖性。在AmB存在下培养的巨噬细胞Ia抗原的表面表达增强；未调理的酵母聚糖、调理的金黄色葡萄球菌或用C3bi或免疫球蛋白G调理的红细胞的吞噬作用似乎反而降低，但结果未达到统计学意义。AmB似乎可激活巨噬细胞，且可能通过对质膜的直接作用来实现。
