重症外科患者血浆凝溶胶蛋白水平与预后的关系。
Relationship of plasma gelsolin levels to outcomes in critically ill surgical patients.
作者信息
Lee Po-Shun, Drager Leslie R, Stossel Thomas P, Moore Francis D, Rogers Selwyn O
机构信息
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Ann Surg. 2006 Mar;243(3):399-403. doi: 10.1097/01.sla.0000201798.77133.55.
OBJECTIVE
To examine the relationship between plasma gelsolin levels and mortality following surgery or trauma.
BACKGROUND
Few simple predictive diagnostic tests are available to predict mortality following surgery or trauma. We hypothesize that plasma concentrations of gelsolin, a protein that responds to injured tissue, might be a predictor of patient outcomes.
METHODS
We conducted a prospective, observational study in the surgical intensive units (ICU) at a tertiary care teaching hospital. A total of 31 patients were enrolled in the study. Chart abstraction was used to gather data about patient demographics, clinical characteristics, and clinical outcomes. Plasma gelsolin concentrations were assessed serially on day 0 through day 5.
RESULTS
Low plasma gelsolin levels were associated with increased risk of death occurring in the ICU. Plasma gelsolin levels lower than 61 mg/L predicted longer ICU stay, prolonged ventilator dependence, and increased overall in-hospital mortality.
CONCLUSION
Plasma gelsolin is a potential prognostic biomarker for critically ill surgical patients. Plasma gelsolin replacement may have therapeutic application.
目的
探讨血浆凝溶胶蛋白水平与手术或创伤后死亡率之间的关系。
背景
几乎没有简单的预测性诊断测试可用于预测手术或创伤后的死亡率。我们假设，凝溶胶蛋白（一种对受损组织有反应的蛋白质）的血浆浓度可能是患者预后的预测指标。
方法
我们在一家三级护理教学医院的外科重症监护病房（ICU）进行了一项前瞻性观察研究。共有31名患者纳入该研究。通过查阅病历收集患者人口统计学、临床特征和临床结局的数据。在第0天至第5天连续评估血浆凝溶胶蛋白浓度。
结果
血浆凝溶胶蛋白水平低与在ICU发生死亡的风险增加相关。血浆凝溶胶蛋白水平低于61mg/L预示着ICU住院时间延长、呼吸机依赖时间延长以及院内总体死亡率增加。
结论
血浆凝溶胶蛋白是危重症外科患者潜在的预后生物标志物。血浆凝溶胶蛋白替代疗法可能具有治疗应用价值。
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