Chistiakova O V, Zubrikhina G N, Rottenberg V I, Nechpaĭ A M
Arkh Patol. 1991;53(3):49-53.
Morphologic and cytophotometric characteristics of tumours and tumour-like lesions of the stomach, colon and rectum from 267 patients were compared in the biopsy material. There was a diploid DNA distribution in the adenomas and tumour-like lesions of colon and rectum. The correlation between the proliferative activity and the epithelial dysplasia degree was noted in adenomas; aneuploid cells were found in 5 adenomas. 53% of gastric carcinoma and 64% of colon and rectum carcinomas were aneuploid (the difference is not significant). Poorly differentiated adenocarcinoma much more frequently (the difference is significant) was found in the aneuploid tumours, well differentiated adenocarcinoma and signet cell carcinoma- in the diploid tumours. DNA index (1.09-1.50) of the aneuploid cells of gastric carcinoma was in 42% cases in the near diploid--triploid region while in colon and rectum carcinoma (60.5%) it was in the triploid--tetraploid region. The type of DNA distribution, particularly in the diploid tumours, should be controlled cytologically.
对267例患者胃、结肠和直肠肿瘤及肿瘤样病变的活检材料进行了形态学和细胞光度学特征比较。结肠和直肠的腺瘤及肿瘤样病变呈二倍体DNA分布。腺瘤中观察到增殖活性与上皮发育异常程度之间存在相关性；在5例腺瘤中发现了非整倍体细胞。53%的胃癌和64%的结肠直肠癌为非整倍体（差异不显著）。非整倍体肿瘤中低分化腺癌更为常见（差异显著），二倍体肿瘤中高分化腺癌和印戒细胞癌更为常见。42%的胃癌非整倍体细胞的DNA指数（1.09 - 1.50）处于近二倍体 - 三倍体区域，而结肠直肠癌（60.5%）的DNA指数处于三倍体 - 四倍体区域。DNA分布类型，尤其是在二倍体肿瘤中，应进行细胞学控制。
