Zubrikhina G N, Sokolova I N, Chistiakova O V
Arkh Patol. 1989;51(8):16-20.
The DNA content was studied in 22 patients (including 10 children) with renal tumours. Renal clear cell carcinomas were mainly diploid (5 of 6 cases); one clear cell and other variants of renal cell carcinoma were aneuploid. There was a correlation between the degree of tumour cell anaplasia and ploidy of renal cell carcinomas: all diploid carcinomas were of I and II degree of anaplasia, aneuploid carcinomas, except one case, were of degree III of anaplasia. 5 out of 9 nephroblastomas were diploid, 4, aneuploid. The distinctive features of nephroblastoma were pronounced proliferative activity of tumour cells and a low DNA index of the aneuploid cell line which in all cases was localized in the vicinity of the diploid region. The remaining tumours (papillary epithelial nephroma, juxtaglomerular cell tumour and malignant schwannoma) were diploid with a relatively low proliferative activity of tumour cells.
对22例（包括10名儿童）肾肿瘤患者的DNA含量进行了研究。肾透明细胞癌主要为二倍体（6例中有5例）；1例透明细胞及其他肾细胞癌变体为非整倍体。肾细胞癌的肿瘤细胞间变程度与倍体之间存在相关性：所有二倍体癌均为Ⅰ级和Ⅱ级间变，非整倍体癌除1例为Ⅲ级间变。9例肾母细胞瘤中有5例为二倍体，4例为非整倍体。肾母细胞瘤的显著特征是肿瘤细胞增殖活性明显，非整倍体细胞系的DNA指数较低，在所有病例中均位于二倍体区域附近。其余肿瘤（乳头状上皮肾瘤、球旁细胞瘤和恶性神经鞘瘤）为二倍体，肿瘤细胞增殖活性相对较低。
