Akema T, Kimura F
Department of Physiology, St. Marianna University School of Medicine, Kawasaki, Japan.
Brain Res. 1991 Apr 12;546(1):143-5. doi: 10.1016/0006-8993(91)91169-2.
An intraventricular injection of a potent GABAB receptor antagonist, 2-hydroxysaclofen, elicited luteinizing hormone (LH) secretion in a dose-dependent manner under the negative feedback condition in ovariectomized estrogen-primed rats. Significant reduction of the effect of 2-hydroxysaclofen by baclofen, a selective GABAB agonist, suggested that the antagonist stimulated LH secretion through interaction with the GABAB receptor. These results provide evidence that the endogenous GABA acting at the GABAB receptor plays a physiological role in controlling basal LH secretion.
在去卵巢并用雌激素预处理的大鼠的负反馈条件下，脑室内注射强效GABAB受体拮抗剂2-羟基氯苯氨丁酸能以剂量依赖的方式引起促黄体生成素（LH）分泌。选择性GABAB激动剂巴氯芬可显著降低2-羟基氯苯氨丁酸的作用，这表明该拮抗剂通过与GABAB受体相互作用刺激LH分泌。这些结果证明，作用于GABAB受体的内源性GABA在控制基础LH分泌中发挥生理作用。
