Akema T, Kimura F
Department of Physiology, St. Marianna University School of Medicine, Kawasaki, Japan.
Brain Res. 1991 Oct 18;562(1):169-72. doi: 10.1016/0006-8993(91)91203-d.
In estrogen-primed ovariectomized rats, intraventricular injections of baclofen, a selective GABAB receptor agonist, either delayed, eliminated or disrupted the steroid-induced LH surge, depending on the time and the dose of the agonist injected. The delay in the onset of the LH surge was not due to a phase delay in the circadian clock, since the retarded LH surge, when observed, had a short duration, terminating in the evening simultaneously with the termination of the normal LH surge in control animals. Rather, rapid disruption of the ongoing LH surge after baclofen injection during the surge suggested a direct involvement of the GABAB receptor-mediated inhibitory component in the LH surge mechanism.
在雌激素预处理的去卵巢大鼠中，脑室内注射巴氯芬（一种选择性GABAB受体激动剂），根据注射激动剂的时间和剂量，要么延迟、消除要么扰乱类固醇诱导的促黄体生成素（LH）高峰。LH高峰起始的延迟并非由于昼夜节律时钟的相位延迟，因为观察到的延迟的LH高峰持续时间较短，在傍晚时结束，与对照动物正常LH高峰的结束时间同步。相反，在LH高峰期间注射巴氯芬后对正在进行的LH高峰的快速扰乱表明，GABAB受体介导的抑制成分直接参与了LH高峰机制。
