[作为抗疟药物的青蒿素相关1,2,4-三恶烷和臭氧化物（1,2,4-三恶戊烷）的研究新进展] - Suppr | 超能文献

[Recent advances in the study of artemisinin-related 1,2,4-trioxanes and ozonides (1,2,4-trioxolanes) as antimalarials].

作者信息

Yang Zhong-shun, Li Ying

机构信息

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

出版信息

Yao Xue Xue Bao. 2005 Dec;40(12):1057-63.

Abstract

摘要

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

相似文献

1

[Recent advances in the study of artemisinin-related 1,2,4-trioxanes and ozonides (1,2,4-trioxolanes) as antimalarials].

Yao Xue Xue Bao. 2005 Dec;40(12):1057-63.

2

Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.

J Med Chem. 1994 Apr 29;37(9):1256-8. doi: 10.1021/jm00035a003.

3

Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate.

Chembiochem. 2005 Apr;6(4):659-67. doi: 10.1002/cbic.200400366.

4

Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.

J Med Chem. 1998 Mar 12;41(6):952-64. doi: 10.1021/jm970711g.

5

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.

J Med Chem. 1995 Jun 23;38(13):2273-5. doi: 10.1021/jm00013a001.

6

Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery.

Org Lett. 2014 Nov 7;16(21):5776-9. doi: 10.1021/ol5028392. Epub 2014 Oct 21.

7

Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

J Org Chem. 2005 Jun 24;70(13):5103-10. doi: 10.1021/jo050385+.

8

Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate.

J Med Chem. 2004 May 6;47(10):2694-9. doi: 10.1021/jm0310333.

9

[Progress in studies on the artemisinin (qinghaosu)-type antimalarials].

Yao Xue Xue Bao. 1998;33(3):234-9.

10

Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.

Chembiochem. 2005 Nov;6(11):2048-54. doi: 10.1002/cbic.200500048.