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Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.

作者信息

Posner G H, Wang D, Cumming J N, Oh C H, French A N, Bodley A L, Shapiro T A

机构信息

Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA.

出版信息

J Med Chem. 1995 Jun 23;38(13):2273-5. doi: 10.1021/jm00013a001.

DOI:10.1021/jm00013a001
PMID:7608890
Abstract
摘要

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1
Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.进一步的证据支持了以碳为中心的自由基对于青蒿素这类1,2,4-三恶烷的高抗疟活性的重要性及限制因素。
J Med Chem. 1995 Jun 23;38(13):2273-5. doi: 10.1021/jm00013a001.
2
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Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity.基于机制的与青蒿素结构相关的新型4-甲基化三氧杂环已烷的设计、合成及体外抗疟测试：以碳为中心的自由基对抗疟活性的重要性
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Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.抗疟药物青蒿素的简化三环1,2,4 - 三氧杂环己烷醇类似物的设计、合成、衍生化及构效关系
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Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.青蒿素家族中具有口服活性、水解稳定的半合成抗疟三氧杂环已烷。
J Med Chem. 1999 Jan 28;42(2):300-4. doi: 10.1021/jm980529v.
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Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action.青蒿素（青蒿琥酯）及相关三氧杂环已烷的抗疟活性：作用机制
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Antimalarial cyclic peroxy ketals.
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J Med Chem. 1995 Feb 17;38(4):607-12. doi: 10.1021/jm00004a006.

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