Benfenati F, Pich E M, Zoli M, Grimaldi R, Fuxe K, Agnati L F
Institute of Human Physiology, University of Modena, Italy.
Brain Res. 1991 Apr 12;546(1):171-5. doi: 10.1016/0006-8993(91)91175-z.
Transient forebrain ischemia induces specific changes in several neurochemical markers in the dorsolateral striatum. In the present paper, the density and distribution of mu and delta opioid receptors were analyzed in rat striatum 7 days after 30 min forebrain ischemia using the 4-vessel occlusion model. A marked (about 70%) decrease in the density of both opioid receptor subtypes was found in the dorsolateral striatum overlapping the areas of histological damage and of D1 dopamine receptor disappearance. Moreover, the density of delta opioid receptors and of the diffuse mu opioid receptors was also affected (30% decrease) in the ventromedial striatum, an area which is substantially spared by the ischemic lesion. In contrast, the striatal patches of mu opioid receptors were not affected in the ventro-medial striatum and were preserved to a large extent in the area of lesion, although their area and receptor density resulted markedly reduced. The impairment of both opioid receptor subtypes suggests that opiate systems, like dopaminergic systems, are involved in the neurochemical changes observed in the striatum after transient forebrain ischemia.
短暂性前脑缺血会在背外侧纹状体中诱导多种神经化学标志物发生特定变化。在本文中，采用四血管闭塞模型，分析了大鼠前脑缺血30分钟后7天纹状体中μ和δ阿片受体的密度及分布情况。在与组织学损伤区域和D1多巴胺受体消失区域重叠的背外侧纹状体中，发现两种阿片受体亚型的密度均显著降低（约70%）。此外，腹内侧纹状体（该区域基本未受缺血性损伤）中的δ阿片受体和弥散性μ阿片受体的密度也受到影响（降低30%）。相比之下，腹内侧纹状体中的μ阿片受体斑块未受影响，且在损伤区域很大程度上得以保留，尽管其面积和受体密度明显降低。两种阿片受体亚型的损伤表明，与多巴胺能系统一样，阿片系统也参与了短暂性前脑缺血后纹状体中观察到的神经化学变化。
