Tang Zhen-Yu, Hu Qiao-Sheng
Department of Chemistry, College of Staten Island and Graduate Center of the City University of New York, Staten Island, New York 10314, USA.
J Org Chem. 2006 Mar 3;71(5):2167-9. doi: 10.1021/jo052369i.
Room-temperature Ni(0)-catalyzed cross-coupling reactions of deactivated aryl chlorides with arylboronic acids with inexpensive triphenylphosphine (PPh3) as a supporting ligand have been accomplished in good to excellent yields. Air-stable Ni(PPh3)2Cl2 has also been established as catalyst precursor, and highly active nickel catalysts were obtained when the reduction of Ni(PPh3)2Cl2 with n-BuLi was carried out in the presence of an aryl chloride.
室温下，以廉价的三苯基膦（PPh₃）作为配体，实现了钝化芳基氯与芳基硼酸的镍（0）催化交叉偶联反应，产率良好至优异。空气稳定的二氯二（三苯基膦）镍（Ⅱ）也已被确定为催化剂前体，当在芳基氯存在下用正丁基锂还原二氯二（三苯基膦）镍（Ⅱ）时，可得到高活性的镍催化剂。
