Jensen J Eric, Miller Jodi, Williamson Peter C, Neufeld Richard W J, Menon Ravi S, Malla Ashok, Manchanda Rahul, Schaefer Betsy, Densmore Maria, Drost Dick J
Brain Imaging Center, McLean Hospital, Belmont, MA 02478-9106, USA.
Psychiatry Res. 2006 Mar 31;146(2):127-35. doi: 10.1016/j.pscychresns.2005.11.004. Epub 2006 Feb 23.
Altered high energy and membrane metabolism, measured with phosphorus magnetic resonance spectroscopy (31P-MRS), has been inconsistently reported in schizophrenic patients in several anatomical brain regions implicated in the pathophysiology of this illness, with little attention to the effects of brain tissue type on the results. Tissue regression analysis correlates brain tissue type to measured metabolite levels, allowing for the extraction of "pure" estimated grey and white matter compartment metabolite levels. We use this tissue analysis technique on a clinical dataset of first episode schizophrenic patients and matched controls to investigate the effect of brain tissue specificity on altered energy and membrane metabolism. In vivo brain spectra from two regions, (a) the fronto-temporal-striatal region and (b) the frontal-lobes, were analyzed from 12 first episode schizophrenic patients and 11 matched controls from a (31)P chemical shift imaging (CSI) study at 4 Tesla (T) field strength. Tissue regression analyses using voxels from each region were performed relating metabolite levels to tissue content, examining phosphorus metabolite levels in grey and white matter compartments. Compared with controls, the first episode schizophrenic patient group showed significantly increased adenosine triphosphate levels (B-ATP) in white matter and decreased B-ATP levels in grey matter in the fronto-temporal-striatal region. No significant metabolite level differences were found in grey or white matter compartments in the frontal cortex. Tissue regression analysis reveals grey and white matter specific aberrations in high-energy phosphates in first episode schizophrenia. Although past studies report inconsistent regional differences in high-energy phosphate levels in schizophrenia, the present analysis suggests more widespread differences that seem to be strongly related to tissue type. Our data suggest that differences in grey and white matter tissue content between past studies may account for some of the variance in the literature.
用磷磁共振波谱法（31P-MRS）测量发现，精神分裂症患者在涉及该疾病病理生理学的几个脑区中，高能和膜代谢存在改变，但报道结果并不一致，且很少关注脑组织类型对结果的影响。组织回归分析将脑组织类型与测量的代谢物水平相关联，从而可以提取“纯”的估计灰质和白质区室代谢物水平。我们在首发精神分裂症患者和匹配对照组的临床数据集上使用这种组织分析技术，以研究脑组织特异性对能量和膜代谢改变的影响。在一项4特斯拉（T）场强的31P化学位移成像（CSI）研究中，对12名首发精神分裂症患者和11名匹配对照组的两个脑区（a）额颞纹状体区和（b）额叶的活体脑谱进行了分析。使用每个区域的体素进行组织回归分析，将代谢物水平与组织含量相关联，检查灰质和白质区室中的磷代谢物水平。与对照组相比，首发精神分裂症患者组在额颞纹状体区的白质中三磷酸腺苷水平（B-ATP）显著升高，而灰质中的B-ATP水平降低。在额叶皮质的灰质或白质区室中未发现显著的代谢物水平差异。组织回归分析揭示了首发精神分裂症患者在高能磷酸盐方面灰质和白质的特异性异常。尽管过去的研究报告了精神分裂症患者高能磷酸盐水平在区域上存在不一致的差异，但目前的分析表明差异更为普遍，且似乎与组织类型密切相关。我们的数据表明，过去研究中灰质和白质组织含量的差异可能是文献中一些差异的原因。
