Zhao Zhiyong, Xu Guojun, Sun Bin, Li Xuzhou, Shen Zhe, Li Shangda, Xu Yi, Huang Manli, Xu Dongrong
Shanghai Key Laboratory of Magnetic Resonance, Key Laboratory of Brain Functional Genomics (MOE & STCSM), Institute of Cognitive Neuroscience, East China Normal University, Shanghai, 200062, China.
Department of Psychiatry & New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, New York, NY, 10032, USA.
Neuroradiology. 2019 May;61(5):575-584. doi: 10.1007/s00234-019-02181-5. Epub 2019 Mar 6.
A recent study has reported that schizophrenia patients show an uncoupled association between intraventricular brain temperature (BT) and cerebral blood flow (CBF). CBF has been found to be closely coupled with spontaneous brain activities (SBAs) derived from resting-state BOLD fMRI metrics. Yet, it is unclear so far whether the relationship between the intraventricular BT and the SBAs may change in patients with adolescent-onset schizophrenia (AOS) compared with that in healthy controls (HCs).
The present study recruited 28 first-episode, drug-naïve AOS patients and 22 matched HCs. We measured the temperature of the lateral ventricles (LV) using diffusion-weighted imaging thermometry and measured SBAs using both regional homogeneity and amplitude of low-frequency fluctuation methods. A nonparametric Wilcoxon rank sum test was used to detect the difference in intraventricular BT between AOS patients and HCs with LV volume, age, and sex as covariates. We also evaluated the relationship between the intraventricular BT and the SBAs using partial correlation analysis controlling for LV volume, age, and sex.
We found that HCs showed a significant negative correlation between the intraventricular BT and the local SBAs in the bilateral putamina and left superior temporal gyrus, while such a correlation was absent in AOS patients. Additionally, no significant difference between the two groups was found in the intraventricular BT.
These findings suggest that AOS patients may experience an uncoupling between intraventricular BT and SBAs in several schizophrenia-related brain areas, which may be associated with the altered relationships among intraventricular BT, CBF, and metabolism.
最近一项研究报告称，精神分裂症患者脑室内脑温度（BT）与脑血流量（CBF）之间的关联不相关。已发现CBF与源自静息态BOLD功能磁共振成像指标的自发脑活动（SBA）密切相关。然而，到目前为止尚不清楚，与健康对照（HC）相比，青少年起病型精神分裂症（AOS）患者脑室内BT与SBA之间的关系是否会发生变化。
本研究招募了28例首发、未用药的AOS患者和22例匹配的HC。我们使用扩散加权成像测温法测量侧脑室（LV）的温度，并使用局部一致性和低频波动幅度方法测量SBA。采用非参数Wilcoxon秩和检验，以LV体积、年龄和性别作为协变量，检测AOS患者和HC之间脑室内BT的差异。我们还使用控制LV体积、年龄和性别的偏相关分析评估脑室内BT与SBA之间的关系。
我们发现，HC双侧壳核和左侧颞上回的脑室内BT与局部SBA之间存在显著负相关，而AOS患者中不存在这种相关性。此外，两组之间的脑室内BT没有显著差异。
这些发现表明，AOS患者在几个与精神分裂症相关的脑区中，脑室内BT与SBA之间可能存在解耦，这可能与脑室内BT、CBF和代谢之间关系的改变有关。
