Krause K H
Department of Internal Medicine, University Hospital, Geneva, Switzerland.
FEBS Lett. 1991 Jul 22;285(2):225-9. doi: 10.1016/0014-5793(91)80806-e.
Intracellular Ca(2+)-storage organelles are found in virtually all eukaryotic cells. They play an important role in the regulation of the cytosolic free Ca2+ concentration and, thereby, in the regulation of cellular activity. Ca(2+)-storage organelles consist, in the simplest model of a Ca2+ pump, of a Ca(2+)-storage protein and a Ca(2+)-release channel. The primary structure of these functionally important proteins of Ca(2+)-storage organelles is similar in different cell types and conserved through evolution. In contrast, their spatial arrangement and, thus, the architecture of Ca(2+)-storage organelles may vary dramatically from one cell type to another.
几乎在所有真核细胞中都能发现细胞内钙储存细胞器。它们在调节胞质游离钙离子浓度方面发挥着重要作用，进而在细胞活动的调节中发挥作用。在最简单的钙泵模型中，钙储存细胞器由一种钙储存蛋白和一个钙释放通道组成。这些对钙储存细胞器功能至关重要的蛋白质的一级结构在不同细胞类型中相似，并在进化过程中保守。相比之下，它们的空间排列，以及因此钙储存细胞器的结构，可能在不同细胞类型之间有很大差异。
