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肝素诱导的血小板减少症:血栓预防的一种并发症。

Heparin-induced thrombocytopenia: a complication of thromboprophylaxis.

作者信息

Kejariwal D

机构信息

Norfolk and Norwich, University Hospital, Colney Lane, Norwich NR4 7UY, UK.

出版信息

J Bone Joint Surg Br. 2006 Mar;88(3):392-3. doi: 10.1302/0301-620X.88B3.17427.

DOI:10.1302/0301-620X.88B3.17427
PMID:16498019
Abstract

Heparin is a drug widely used for thromboprophylaxis or treatment in many clinical situations. However, it can cause serious adverse effects, including thrombocytopenia, which is a potentially life-threatening condition. Unfortunately, heparin-induced thrombocytopenia is generally under-recognised and under-diagnosed. A case of heparin-induced thrombocytopenia occurring in a post-operative orthopaedic patient in association with prophylactic low-molecular-weight heparin is described.

摘要

肝素是一种在许多临床情况下广泛用于血栓预防或治疗的药物。然而,它可引起严重不良反应,包括血小板减少症,这是一种潜在的危及生命的病症。不幸的是,肝素诱导的血小板减少症通常未得到充分认识和诊断。本文描述了一例骨科术后患者发生的与预防性低分子量肝素相关的肝素诱导的血小板减少症病例。

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1
Heparin-induced thrombocytopenia: a complication of thromboprophylaxis.肝素诱导的血小板减少症:血栓预防的一种并发症。
J Bone Joint Surg Br. 2006 Mar;88(3):392-3. doi: 10.1302/0301-620X.88B3.17427.
2
Should patients be informed about the risk of heparin-induced thrombocytopenia before prolonged low-molecular-weight heparin thromboprophylaxis post-trauma/orthopedic surgery?在创伤/骨科手术后进行长时间的低分子量肝素血栓预防之前,是否应该告知患者肝素诱导的血小板减少症的风险?
Eur J Haematol. 2007 Sep;79(3):187-90. doi: 10.1111/j.1600-0609.2007.00891.x. Epub 2007 Jul 26.
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Heparin-induced thrombocytopenia with acute aortic and renal thrombosis in a patient treated with low-molecular-weight heparin.一名接受低分子量肝素治疗的患者发生肝素诱导的血小板减少症并伴有急性主动脉和肾血栓形成。
Eur J Vasc Endovasc Surg. 2005 Feb;29(2):209-12. doi: 10.1016/j.ejvs.2004.09.014.
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Heparin induced thrombocytopenia after low molecular weight heparin treatment: a case report.
Riv Eur Sci Med Farmacol. 1996 Sep-Dec;18(5-6):225-8.
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The incidence and clinical features of heparin-induced thrombocytopenia.肝素诱导的血小板减少症的发病率及临床特征。
Semin Hematol. 2005 Jul;42(3 Suppl 3):S3-8. doi: 10.1053/j.seminhematol.2005.05.012.
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[Heparin induced thrombocytopenia type II after the use of low-molecular weight heparin. Case report and review of the literature].[使用低分子量肝素后发生的Ⅱ型肝素诱导的血小板减少症。病例报告及文献复习]
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Endovascular management of acute infrarenal aortic thrombosis caused by heparin-induced thrombocytopenia in a patient treated with low molecular weight heparin.低分子量肝素治疗患者中肝素诱导的血小板减少症所致急性肾下腹主动脉血栓形成的血管内治疗
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Fondaparinux-related thrombocytopenia in a previous low-molecular-weight heparin (LMWH)-induced heparin-induced thrombocytopenia (HIT).既往低分子肝素(LMWH)诱导的肝素诱导的血小板减少症(HIT)中出现的磺达肝癸钠相关血小板减少症。
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Heparin, low molecular weight heparin, and heparin-induced thrombocytopenia in the ICU.
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