Wang Zhao-hui, Luo Feng, Liu Xiao-mei
The Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China.
Yao Xue Xue Bao. 2005 Nov;40(11):1051-3.
To explore the prevention of atherosclerosis by PPARy agonist rosiglitazone.
24 male New Zealand white rabbits weighing 1.8 to 2.2 kg were randomly divided into 3 groups: control group, normal rabbit chow; cholesterol group, 1% cholesterol diet; rosiglitazone group, 1% cholesterol diet supplemented with rosiglitazone 0.5 mg x kg(-1) x d(-1) for 6 weeks. Rabbits in cholesterol group and rosiglitazone group were sequentially fed 1% cholesterol-containing diet for 16 weeks. At the end of the experiment, blood glucose, serum lipids levels, ratio of plaque area to aorta area and ratio of intima to media were determined.
Hypercholesterolemia was successfully reproduced in rabbits. Adnimistration of rosiglitazone significantly decreased serum TC and LDL-C. The ratio of intima to media and ratio of plaque area to aorta area were also reduced.
Rosiglitazone could prevent atherosclerosis by decreasing levels of TC and LDL-C.
探讨过氧化物酶体增殖物激活受体γ（PPARγ）激动剂罗格列酮对动脉粥样硬化的预防作用。
将24只体重1.8至2.2千克的雄性新西兰白兔随机分为3组：对照组，给予正常兔饲料；胆固醇组，给予1%胆固醇饮食；罗格列酮组，给予1%胆固醇饮食并补充罗格列酮0.5毫克/千克/天，持续6周。胆固醇组和罗格列酮组的兔子先后给予含1%胆固醇的饮食16周。实验结束时，测定血糖、血脂水平、斑块面积与主动脉面积之比以及内膜与中膜之比。
成功在兔子中复制了高胆固醇血症。给予罗格列酮可显著降低血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）。内膜与中膜之比以及斑块面积与主动脉面积之比也降低。
罗格列酮可通过降低TC和LDL-C水平预防动脉粥样硬化。
