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《基因组音乐》的制作。

The making of "The Genoma Music.".

作者信息

Sánchez Sousa Aurora, Baquero Fernando, Nombela César

机构信息

Unidad de Micología, Servicio de Microbiología, Hospital Ramón y Cajal, Carretera de Colmenar Km 9,100, 28034 Madrid, Spain.

出版信息

Rev Iberoam Micol. 2005 Dec;22(4):242-8. doi: 10.1016/s1130-1406(05)70050-4.

Abstract

Both genetic and musical sequences are ordered structures composed of combinations of a small number of elements, of nucleotides and musical notes. In the case of the genome, the emergence of cellular functions makes the order meaningful; in the case of musical sequences, the consequence of order is the production of mysterious esthetical effects in the human mind. Can any musical significance be found in DNA sequence? In this work, we present the technique used to convert DNA sequences into musical sequences. The musical equivalent of the sequence of a number of genes, either of fungal origin, such as Candida albicans or Sacharomyces cerevisiae (SLT2), or belonging to the human genome (genes involved in Alzheimer syndrome, blindness, and deafness such as Connexine 26 gene) has been obtained. Non-coding sequences are also important in life and music. The non-coding alphoid sequence has also been translated into a musical sequence, in this case using Fibonacci golden number basic series as structural helper. The elementary musical sequence derived from DNA sequence has served as an imposing frame in which rhythms, sounds, and melodies have been harmonically inserted. The Genoma Music Project is essentially a creative metaphor of the basic unity between the human mind and the natural ordered structure of life.

摘要

基因序列和音乐序列都是由少量元素(核苷酸和音符)组合而成的有序结构。就基因组而言,细胞功能的出现使这种顺序具有意义;就音乐序列而言,顺序的结果是在人类脑海中产生神秘的美学效果。在DNA序列中能发现任何音乐意义吗?在这项工作中,我们展示了将DNA序列转化为音乐序列的技术。我们已经获得了一些基因序列的音乐等效物,这些基因要么来自真菌,如白色念珠菌或酿酒酵母(SLT2),要么属于人类基因组(与阿尔茨海默综合征、失明和失聪相关的基因,如连接蛋白26基因)。非编码序列在生命和音乐中也很重要。非编码的α卫星序列也已被翻译成音乐序列,在这种情况下使用斐波那契黄金数基本数列作为结构辅助。从DNA序列衍生出的基本音乐序列成为了一个极具感染力的框架,节奏、声音和旋律在其中和谐地嵌入。基因组音乐计划本质上是人类思维与生命自然有序结构之间基本统一性的一种创造性隐喻。

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