Loo Ray Mun, Ariyarajah Vignendra, Oh Christina, Shen Liang, Aw Marion M, Prabhakaran K
Department of Pediatrics, Nassau University Medical Center, East Meadow, NY 11554, USA.
Pediatr Transplant. 2006 Feb;10(1):55-9. doi: 10.1111/j.1399-3046.2005.00399.x.
Tacrolimus (FK506) and cyclosporine, synonymous with immunosuppressive therapy in organ transplantation, are not spared of potential adverse effects such as nephrotoxicity. We retrospectively compared their effects on cGFR in a post-OLT pediatric population. cGFRs of 32 patients from the LTUNUHS either on tacrolimus (group 1) or cyclosporine (group 2) from pretransplantation, transplantation and 3, 6, 9, 12, 18, 24, 30 and 36 months post-transplantation were compared. 95% CI and p-values were calculated for comparison with p < 0.05 considered significant. Longitudinal data analysis revealed no significant cGFR difference between groups 1 and 2 (p = 0.154). However, there was a significant difference in cGFR with time after transplantation (p < 0.0001). The mean difference score between both treatment groups was 277.92 (95% CI = 88.13-643.97). The survival rate post-OLT was 84.4%. In this retrospective sex-matched case controlled study of LTUNUHS patients, there was no difference between tacrolimus and cyclosporine on renal function. However, there was significant difference in cGFR with time post-OLT (p < 0.0001). The reason for this observation could be multifactorial.
他克莫司（FK506）和环孢素是器官移植免疫抑制治疗的代名词，也难免会有潜在的不良反应，如肾毒性。我们回顾性比较了它们对肝移植术后儿科患者群体中估算肾小球滤过率（cGFR）的影响。比较了来自罗切斯特大学医学中心（LTUNUHS）的32例患者在移植前、移植时以及移植后3、6、9、12、18、24、30和36个月时使用他克莫司（第1组）或环孢素（第2组）的cGFR。计算95%置信区间（CI）和p值进行比较，p<0.05被认为具有统计学意义。纵向数据分析显示第1组和第2组之间的cGFR没有显著差异（p = 0.154）。然而，移植后cGFR随时间有显著差异（p < 0.0001）。两个治疗组之间的平均差异得分是277.92（95%CI = 88.13 - 643.97）。肝移植术后生存率为84.4%。在这项对罗切斯特大学医学中心患者进行的回顾性性别匹配病例对照研究中，他克莫司和环孢素对肾功能的影响没有差异。然而，肝移植术后cGFR随时间有显著差异（p < 0.0001）。这一观察结果的原因可能是多因素的。
