Valtonen Kirsi M, Goksör Lars-Ake, Jonsson Olof, Mellström Dan, Alaranta Hannu T, Viikari-Juntura Eira R
Department of Rehabilitation Medicine, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
Arch Phys Med Rehabil. 2006 Mar;87(3):376-82. doi: 10.1016/j.apmr.2005.11.004.
To assess the prevalence of osteoporosis and osteopenia in adults with meningomyelocele and to explore whether neurologic level, ambulatory status, and other medical problems are associated with bone mineral density (BMD).
A cross-sectional study, including a self-administered questionnaire and clinical assessment.
Outpatient referral clinic in Sweden.
Twenty-one adults (mean age, 30 y) with meningomyelocele admitted to the Young Adult Teams in Göteborg and Boras, Sweden.
Not applicable.
BMD in the lumbar spine and hip and forearm measured with dual x-ray absorptiometry.
Seven (33%) subjects had osteoporosis in at least 1 of the measured sites. Three patients had osteopenia and 2 had osteoporosis in the lumbar spine. Among the 15 subjects whose BMD of the hip region could be reliably measured, 7 (47%) had osteoporosis in the femoral neck or trochanteric region of the hip. Subjects with other medical problems commonly occurring in meningomyelocele had lower BMD in the femoral neck and trochanteric region of the hip than subjects without such factors. Ambulation alone showed only a tendency to be associated with BMD of the femoral neck, whereas the effect of other medical risk factors on BMD of the femoral neck was stronger among the nonambulators than the ambulators.
Our results show that osteoporosis is a medical problem to be considered when treating and rehabilitating patients with meningomyelocele.
评估脊髓脊膜膨出症成人患者骨质疏松症和骨质减少症的患病率，并探讨神经平面、行走状态及其他医学问题是否与骨密度（BMD）相关。
一项横断面研究，包括自行填写的问卷和临床评估。
瑞典的门诊转诊诊所。
瑞典哥德堡和博拉斯的青年成人团队收治的21例脊髓脊膜膨出症成人患者（平均年龄30岁）。
不适用。
采用双能X线吸收法测量腰椎、髋部和前臂的骨密度。
7例（33%）受试者至少在1个测量部位存在骨质疏松症。3例患者存在骨质减少，2例患者腰椎存在骨质疏松症。在15例髋部骨密度可可靠测量的受试者中，7例（47%）在髋部股骨颈或大转子区域存在骨质疏松症。患有脊髓脊膜膨出症常见其他医学问题的受试者，其髋部股骨颈和大转子区域的骨密度低于无此类因素的受试者。仅行走状态与股骨颈骨密度仅显示出一种关联趋势，而在非行走者中，其他医学风险因素对股骨颈骨密度的影响比行走者更强。
我们的结果表明，骨质疏松症是脊髓脊膜膨出症患者治疗和康复时需要考虑的一个医学问题。
