Pfanner N, Söllner T, Neupert W
Institut für Physiologische Chemie, Universität München, FRG.
Trends Biochem Sci. 1991 Feb;16(2):63-7. doi: 10.1016/0968-0004(91)90026-r.
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42) and p32 which have a role in initial steps of protein import. The first three components are present in a multi-subunit complex that catalyses recognition and membrane insertion of precursor proteins.
在胞质溶胶中合成的前体蛋白特异性靶向各种细胞器是细胞内蛋白质运输的核心方面。数百种不同的蛋白质从胞质溶胶被转运到线粒体中。最近的研究已经鉴定出线粒体外膜蛋白MOM19、MOM72、MOM38（约为ISP42）和p32，它们在蛋白质转运的起始步骤中发挥作用。前三个组分存在于一个多亚基复合物中，该复合物催化前体蛋白的识别和膜插入。
