[不同病因的焦虑和抑郁状态下生物源嘧啶的生物合成]

[Biosynthesis of biogenic pyrimidines in anxiety and depressive states of different etiologies].

作者信息

Karkishchenko N N, Stradomskiĭ B V, Makliakov Iu S, Zaika V G

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(4):73-4.

Abstract

Biosynthesis of endogenous pyrimidines was investigated in 37 patients with anxiety, anxious-depressive, depressive and hypochondriac syndromes emerging in schizophrenia and manic-depressive psychosis against a control group of healthy subjects (n-20) andopiate abusers (n-10). It was found that depressive and anxiety states in the examinees were associated with inhibition of endogenous pyrimidines synthesis likely to result in abnormal depression and anxiety levels.

摘要

对37例患有精神分裂症和躁郁症中出现的焦虑、焦虑抑郁、抑郁和疑病综合征的患者，针对一组健康对照者（n = 20）和阿片类药物滥用者（n = 10），研究了内源性嘧啶的生物合成。结果发现，受检者的抑郁和焦虑状态与内源性嘧啶合成的抑制有关，这可能导致抑郁和焦虑水平异常。