Nébavi François, Ayala Francisco J, Renaud François, Bertout Sébastien, Eholié Serge, Moussa Koné, Mallié Michèle, de Meeûs Thierry
Laboratoire de Parasitologie et Mycologie Médicale, EA 2413, Faculté de Pharmacie, 34060 Montpellier Cedex 1, France.
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3663-8. doi: 10.1073/pnas.0511328103. Epub 2006 Feb 24.
We have investigated the genotype at 14 enzyme-encoding loci in 275 isolates of the pathogenic yeast Candida albicans sampled from 42 HIV-positive patients (all but one with AIDS) from Abidjan (Côte d'Ivoire). We separately analyzed the following variables: patient, residence, age, gender, T cell count, hospitalization (yes or no), drug treatment, date of sampling, multilocus genotype, and serotype. The most important factors contributing to the genetic variability of C. albicans are individual patient and gender. Our data manifest that the population size of the parasite is relatively small within each patient, although larger in women than in men, and that, at least for the patients involved in the study, the transmission rate of C. albicans between human adults is very low. Most important is the inference that the prevailing mode of reproduction of C. albicans in natural populations is clonal, so that sexual reproduction is extremely rare, if it occurs at all.
我们对从科特迪瓦阿比让42名艾滋病毒阳性患者（除1名外均患有艾滋病）中采集的275株致病性白色念珠菌进行了14个酶编码位点的基因型研究。我们分别分析了以下变量：患者、居住地、年龄、性别、T细胞计数、住院情况（是或否）、药物治疗、采样日期、多位点基因型和血清型。导致白色念珠菌遗传变异的最重要因素是个体患者和性别。我们的数据表明，尽管女性体内的寄生虫种群规模大于男性，但每位患者体内的寄生虫种群规模相对较小，并且至少对于参与研究的患者而言，白色念珠菌在成年人间的传播率非常低。最重要的是推断出，白色念珠菌在自然种群中的主要繁殖方式是克隆性的，因此有性繁殖极为罕见，即便确实发生过。
