Fraser John K, Schreiber Ronda, Strem Brian, Zhu Min, Alfonso Zeni, Wulur Isabella, Hedrick Marc H
Cytori Therapeutics Inc., San Diego, CA, USA.
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S33-7. doi: 10.1038/ncpcardio0444.
Recent preclinical and clinical studies have suggested that adult stem cells have the ability to promote the retention or restoration of cardiac function in acute and chronic ischemia. Published clinical studies have used autologous donor cells, including skeletal muscle myoblasts, cultured peripheral blood cells, or bone marrow cells. However, our research and that of others indicates that human adipose tissue is an alternative source of cells with potential for cardiac cell therapy. These findings include the presence of cells within adipose tissue that can differentiate into cells expressing a cardiomyocytic or endothelial phenotype, as well as angiogenic and antiapoptotic growth factors. This potential is supported by preclinical studies in large animals.
近期的临床前和临床研究表明，成体干细胞能够促进急性和慢性缺血时心脏功能的保留或恢复。已发表的临床研究使用了自体供体细胞，包括骨骼肌成肌细胞、培养的外周血细胞或骨髓细胞。然而，我们的研究以及其他研究表明，人类脂肪组织是具有心脏细胞治疗潜力的细胞的另一种来源。这些发现包括脂肪组织内存在可分化为表达心肌细胞或内皮细胞表型的细胞，以及血管生成和抗凋亡生长因子。大型动物的临床前研究支持了这种潜力。
