Rauch A, Droz S, Zimmerli S, Leib S L
Clinic and Policlinic for Infectious Diseases, University Hospital, Inselspital, Bern, Switzerland.
Infection. 2006 Feb;34(1):35-8. doi: 10.1007/s15010-006-4151-7.
Dysphagia is seldom caused by tetanus; however, it is a common symptom of tetanus. Treating patients with tetanus is a rare event in industrialized countries and awareness is needed to recognize early signs of this serious disease. In Switzerland, the most recently reported tetanus cases occurred in elderly women with insufficient seroprotection.
We report on three elderly women presenting with dysphagia as an initial symptom of tetanus.
Generalized tetanus was diagnosed in two patients upon admission, the third presented with cephalic tetanus with secondary generalization. All three patients had undetectable levels of tetanus antibodies and had no documented prior tetanus immunizations. Cultures of wound swabs grew Clostridium tetani in all cases. Electromyography was highly suggestive for tetanus in two patients. Treatment involved mechanical ventilation, intravenous benzodiazepine and metronidazole therapy, and active and passive tetanus immunization. The disease had a favorable outcome in two cases and was fatal in one.
Tetanus remains a threat in patients with insufficient seroprotection and efforts are needed to improve tetanus immunization in these individuals. Tetanus should be considered in the differential diagnosis of dysphagia.
破伤风很少导致吞咽困难;然而,它是破伤风的常见症状。在工业化国家,治疗破伤风患者是罕见的情况,需要提高对这种严重疾病早期症状的认识。在瑞士,最近报告的破伤风病例发生在血清保护不足的老年女性中。
我们报告了三名以吞咽困难为破伤风初始症状的老年女性。
两名患者入院时被诊断为全身性破伤风,第三名患者表现为头部破伤风继发全身性发作。所有三名患者的破伤风抗体水平均检测不到,且既往无破伤风免疫接种记录。所有病例的伤口拭子培养均生长出破伤风梭菌。两名患者的肌电图高度提示破伤风。治疗包括机械通气、静脉注射苯二氮䓬和甲硝唑治疗,以及主动和被动破伤风免疫接种。两例患者病情转归良好,一例死亡。
破伤风对血清保护不足的患者仍然构成威胁,需要努力改善这些个体的破伤风免疫接种情况。在吞咽困难的鉴别诊断中应考虑破伤风。