Vokurka Samuel, Bystrická Eva, Koza Vladimír, Scudlová Jana, Pavlicová Vladislava, Valentová Dana, Visokaiová Maria, Misaniová Lubica
Department of Haemato-Oncology, University Hospital, Alej Svobody 80, Plzen, 304 60, Czech Republic.
Support Care Cancer. 2006 Sep;14(9):974-6. doi: 10.1007/s00520-006-0031-z. Epub 2006 Feb 25.
Study on the normal saline vs povidone-iodine mouthwashes for oral mucositis (OM) prophylaxis in patients after high-dose chemotherapy comprising bischloroethyl nitrosourea etoposide ara-C melphalan (BEAM) or high-dose melphalan (HD-L-PAM) followed by autologous peripheral stem cell transplantation indicated that females have higher a incidence of OM compared to men, as reported by [Vokurka et al. 13:554-558, (2005)]. The multivariable analysis of larger cohort of 148 patients compliant with the original study protocol confirmed female gender to be an independent risk factor and predictor for OM. The HD-L-PAM (200 mg/m2) conditioning regimen revealed to be more toxic compared to BEAM as for incidence of OM grades 3-4 World Health Organization score. Body mass index, age, mouthwash solution used, and CD34+ cell number in the autologous graft were verified not to have an impact on OM incidence in this group of patients.
关于生理盐水与聚维酮碘漱口水在接受包含双氯乙基亚硝脲、依托泊苷、阿糖胞苷、美法仑（BEAM）或大剂量美法仑（HD-L-PAM）的高剂量化疗后进行自体外周干细胞移植的患者中预防口腔黏膜炎（OM）的研究表明，正如[Vokurka等人，13:554 - 558，（2005年）]所报道的，女性发生OM的发生率高于男性。对符合原始研究方案的148例患者的更大队列进行多变量分析证实，女性性别是OM的独立危险因素和预测因素。就世界卫生组织3 - 4级评分的OM发生率而言，HD-L-PAM（200 mg/m²）预处理方案显示比BEAM毒性更大。在这组患者中，已证实体重指数、年龄、使用的漱口水溶液以及自体移植物中的CD34 +细胞数量对OM发生率没有影响。
