术前粗针穿刺活检不会增加乳腺癌患者的局部复发率。
Preoperative core needle biopsy does not increase local recurrence rate in breast cancer patients.
作者信息
Fitzal Florian, Sporn Emanuel P, Draxler Wolfgang, Mittlböck Martina, Taucher Susanne, Rudas Margaretha, Riedl Otto, Helbich Thomas H, Jakesz Raimund, Gnant Michael
机构信息
Department of Surgery, General Hospital, University Vienna, Waehringer Guertd 18-20, 1090 Vienna, Austria.
出版信息
Breast Cancer Res Treat. 2006 May;97(1):9-15. doi: 10.1007/s10549-005-6935-3.
OBJECTIVE
Several case reports and clinical studies in the literature demonstrate needle track seeding after core needle biopsy in patients with breast cancer in up to 50% of cases. The impact of this observation on local recurrence and overall survival rate is, however, not fully investigated.
PATIENTS AND DESIGN
We retrospectively analysed 719 patients after breast conserving surgery and postoperative radiotherapy for stage I and II breast cancer. We divided this group into patients with (189) and without (530) preoperative core needle biopsy. Demographic data, local recurrence and overall survival rate were compared between these two groups.
RESULT
Preoperative core needle biopsy did not significantly influence the local free recurrence rate (median follow-up time of 78 and 71 months, respectively). The prognostic factors and the postoperative therapy did not differ significantly between the two groups.
CONCLUSION
Preoperative core needle biopsy seems to have no detrimental impact on local recurrence and overall survival after breast conserving surgery and postoperative radiotherapy.
目的
文献中的几例病例报告和临床研究表明，乳腺癌患者在进行粗针活检后，针道种植的发生率高达50%。然而，这一现象对局部复发和总生存率的影响尚未得到充分研究。
患者与设计
我们回顾性分析了719例接受保乳手术及术后放疗的I期和II期乳腺癌患者。我们将该组患者分为术前接受粗针活检的患者（189例）和未接受粗针活检的患者（530例）。比较了两组患者的人口统计学数据、局部复发率和总生存率。
结果
术前粗针活检对局部无复发生存率没有显著影响（两组的中位随访时间分别为78个月和71个月）。两组的预后因素和术后治疗无显著差异。
结论
术前粗针活检似乎对保乳手术及术后放疗后的局部复发和总生存率没有不利影响。
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